Sequesterpene Lactones Isolated from a Brazilian Cerrado Plant ( Spp. As Anti-Proliferative Compounds, Characterized by Functional and Proteomic Analysis, Are Candidates for New Therapeutics in Glioblastoma

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 Jul 8

PMID 32630308

Citations 5

Authors

Clarice Izumi

Helen Julie Laure

Nayara Goncalves Barbosa

Carolina Hassibe Thome

Germano Aguiar Ferreira

Joao Paulo Barreto Sousa

Norberto Peporine Lopes

Jose Cesar Rosa

Affiliations

Soon will be listed here.

Abstract

Gliomas are responsible for more than 60% of all primary brain tumors. Glioblastoma multiforme (GBM), a grade IV tumor (WHO), is one of the most frequent and malignant gliomas. Despite two decades of advances in the discovery of new markers for GBM, the chemotherapy of choice falls to temozolomide after surgery and radiotherapy, which are not enough to increase the survival of patients to more than 15 months. It is urgent to discover new anti-glioma compounds. Many compounds derived from natural products have been used in the development of anti-tumor drugs. In this work, we have screened six low molecular weight sesquiterpene lactones, isolated from spp., and studied their function as anti-proliferative agents against GBM strains. We demonstrated that two of them, goyazensolide and lychnofolide, were effective in reducing cell viability, preventing the formation of anchorage-dependent colony and were able to pass through a mimetic blood-brain barrier making them candidates for glioma therapy, being more potent than temozolomide, according to in vitro assays for the cell lines tested. Proteomic analysis revealed a number of altered proteins involved in glycolytic metabolism and cellular catabolism.

Citing Articles

Sesquiterpene Lactones as Promising Anti-Glioblastoma Drug Candidates Exerting Complex Effects on Glioblastoma Cell Viability and Proneural-Mesenchymal Transition.

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Metabolic Profiling of Species with Antitumor Activity.

Lima N, Preet G, Marqui S, Falcoski T, Navegante G, Soares C Molecules. 2022; 27(15).

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Efficacy and Safety of Temozolomide Combined with Radiotherapy in the Treatment of Malignant Glioma.

Wei S, Li J J Healthc Eng. 2022; 2022:3477918.

PMID: 35211253 PMC: 8863446. DOI: 10.1155/2022/3477918.

Proteomics and Nucleotide Profiling as Tools for Biomarker and Drug Target Discovery.

Honore B, Rice G, Vorum H Int J Mol Sci. 2021; 22(20).

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Natural Compounds in Glioblastoma Therapy: Preclinical Insights, Mechanistic Pathways, and Outlook.

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PMID: 34065960 PMC: 8150927. DOI: 10.3390/cancers13102317.

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