Cancer Drug Resistance: Redox Resetting Renders a Way

Overview

Journal Oncotarget

Specialty Oncology

Date 2016 Apr 9

PMID 27057637

Citations 84

Authors

Yuan Liu

Qifu Li

Li Zhou

Na Xie

Edouard C Nice

Haiyuan Zhang

Canhua Huang

Yunlong Lei

Affiliations

Soon will be listed here.

Abstract

Disruption of redox homeostasis is a crucial factor in the development of drug resistance, which is a major problem facing current cancer treatment. Compared with normal cells, tumor cells generally exhibit higher levels of reactive oxygen species (ROS), which can promote tumor progression and development. Upon drug treatment, some tumor cells can undergo a process of 'Redox Resetting' to acquire a new redox balance with higher levels of ROS accumulation and stronger antioxidant systems. Evidence has accumulated showing that the 'Redox Resetting' enables cancer cells to become resistant to anticancer drugs by multiple mechanisms, including increased rates of drug efflux, altered drug metabolism and drug targets, activated prosurvival pathways and inefficient induction of cell death. In this article, we provide insight into the role of 'Redox Resetting' on the emergence of drug resistance that may contribute to pharmacological modulation of resistance.

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