The Effect of Mirabegron on Energy Expenditure and Brown Adipose Tissue in Healthy Lean South Asian and Europid Men

Overview

Journal Diabetes Obes Metab

Specialty Endocrinology

Date 2020 Jun 20

PMID 32558052

Citations 17

Authors

Kimberly J Nahon

Laura G M Janssen

Aashley S D Sardjoe Mishre

Manu P Bilsen

Jari A van der Eijk

Kani Botani

Lisanne A Overduin

Jonatan R Ruiz

Jedrzej Burakiewicz

Oleh Dzyubachyk

Andrew G Webb

Hermien E Kan

Jimmy F P Berbee

Jan-Bert van Klinken

Ko Willems van Dijk

Michel van Weeghel

Frederic M Vaz

Tamer Coskun

Ingrid M Jazet

Sander Kooijman

Borja Martinez-Tellez

Mariette R Boon

Patrick C N Rensen

Affiliations

Soon will be listed here.

Abstract

Aim: To compare the effects of cold exposure and the β3-adrenergic receptor agonist mirabegron on plasma lipids, energy expenditure and brown adipose tissue (BAT) activity in South Asians versus Europids.

Materials And Methods: Ten lean Dutch South Asian (aged 18-30 years; body mass index [BMI] 18-25 kg/m ) and 10 age- and BMI-matched Europid men participated in a randomized, double-blinded, cross-over study consisting of three interventions: short-term (~ 2 hours) cold exposure, mirabegron (200 mg one dose p.o.) and placebo. Before and after each intervention, we performed lipidomic analysis in serum, assessed resting energy expenditure (REE) and skin temperature, and measured BAT fat fraction by magnetic resonance imaging.

Results: In both ethnicities, cold exposure increased the levels of several serum lipid species, whereas mirabegron only increased free fatty acids. Cold exposure increased lipid oxidation in both ethnicities, while mirabegron increased lipid oxidation in Europids only. Cold exposure and mirabegron enhanced supraclavicular skin temperature in both ethnicities. Cold exposure decreased BAT fat fraction in both ethnicities. After the combination of data from both ethnicities, mirabegron decreased BAT fat fraction compared with placebo.

Conclusions: In South Asians and Europids, cold exposure and mirabegron induced beneficial metabolic effects. When combining both ethnicities, cold exposure and mirabegron increased REE and lipid oxidation, coinciding with a higher supraclavicular skin temperature and lower BAT fat fraction.

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