Synthesis of Pyrrolidinedione-fused Hexahydropyrrolo[2,1-]isoquinolines Via Three-component [3 + 2] Cycloaddition Followed by One-pot -allylation and Intramolecular Heck Reactions

Overview

Journal Beilstein J Org Chem

Specialty Chemistry

Date 2020 Jun 20

PMID 32550934

Citations 3

Authors

Xiaoming Ma

Suzhi Meng

Xiaofeng Zhang

Qiang Zhang

Shenghu Yan

Yue Zhang

Wei Zhang

Affiliations

Soon will be listed here.

Abstract

Two kinds of [3 + 2] cycloaddition intermediates generated from the three-component reactions of 2-bromobenzaldehydes and maleimides with amino esters or amino acids were used for a one-pot -allylation and intramolecular Heck reactions to form pyrrolidinedione-fused hexahydropyrrolo[2,1-]isoquinolines. The multicomponent reaction was combined with one-pot reactions to make a synthetic method with good pot, atom and step economy. MeCN was used as a preferable green solvent for the reactions.

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