Synthesis of Pyrrolo[2,1-a]isoquinolines by Multicomponent 1,3-dipolar Cycloaddition

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2013 Mar 1

PMID 23446920

Citations 4

Authors

Florea Dumitrascu

Emilian Georgescu

Florentina Georgescu

Marcel Mirel Popa

Denisa Dumitrescu

Affiliations

Soon will be listed here.

Abstract

Pyrrolo[2,1-a]isoquinoline derivatives were synthesized by one-pot three-component reactions starting from isoquinoline, 2-bromoacetophenones and different non-symmetrical acetylenic dipolarophiles using 1,2-epoxypropane as solvent. The structure of the compounds was assigned by IR and NMR spectroscopy.

Citing Articles

Highly diastereoselective construction of novel dispiropyrrolo[2,1-]isoquinoline derivatives multicomponent 1,3-dipolar cycloaddition of cyclic diketones-based tetrahydroisoquinolinium -ylides.

Boudriga S, Haddad S, Askri M, Soldera A, Knorr M, Strohmann C RSC Adv. 2022; 9(20):11082-11091.

PMID: 35558642 PMC: 9092959. DOI: 10.1039/c8ra09884k.

Synthesis of 1-(2-Fluorophenyl)pyrazoles by 1,3-Dipolar Cycloaddition of the Corresponding Sydnones.

Dumitrescu D, Shova S, Draghici C, Popa M, Dumitrascu F Molecules. 2021; 26(12).

PMID: 34204262 PMC: 8235238. DOI: 10.3390/molecules26123693.

Synthesis of pyrrolidinedione-fused hexahydropyrrolo[2,1-]isoquinolines via three-component [3 + 2] cycloaddition followed by one-pot -allylation and intramolecular Heck reactions.

Ma X, Meng S, Zhang X, Zhang Q, Yan S, Zhang Y Beilstein J Org Chem. 2020; 16:1225-1233.

PMID: 32550934 PMC: 7277624. DOI: 10.3762/bjoc.16.106.

Sydnone C-4 heteroarylation with an indolizine ring via Chichibabin indolizine synthesis.

Albota F, Caira M, Draghici C, Dumitrascu F, Dumitrescu D Beilstein J Org Chem. 2017; 12:2503-2510.

PMID: 28144319 PMC: 5238577. DOI: 10.3762/bjoc.12.245.

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