One-Pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3 + 2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-Free Click Reactions

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2019 Feb 13

PMID 30743991

Citations 5

Authors

Xiaoming Ma

Xiaofeng Zhang

Weiqi Qiu

Wensheng Zhang

Bruce Wan

Jason Evans

Wei Zhang

Affiliations

Soon will be listed here.

Abstract

A one-pot synthesis of triazolobenzodiazepine-containing polycyclic compounds is introduced. The reaction process involves a decarboxylative three-component [3 + 2] cycloaddition of nonstabilized azomethine ylides, -propargylation, and intramolecular click reactions.

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