Double 1,3-Dipolar Cycloadditions of Two Nonstabilized Azomethine Ylides for Polycyclic Pyrrolidines

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2019 Mar 19

PMID 30883128

Citations 6

Authors

Xiaofeng Zhang

Weiqi Qiu

Jason Evans

Manpreet Kaur

Jerry P Jasinski

Wei Zhang

Affiliations

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Abstract

Nonstabilized azomethine ylides derived from decarboxylation of oxazolidin-5-ones were used for double 1,3-dipolar cycloadditions in diastereoselective synthesis of pyrrolidine-containing tetracyclic compounds. This is the first example of one-pot and five-component reactions involving two nonstabilized azomethine ylides. Only CO and water were generated as byproducts.

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