LncRNA H19 Gene Rs2839698 Polymorphism is Associated with a Decreased Risk of Colorectal Cancer in a Chinese Han Population: A Case-control Study

Overview

Journal J Clin Lab Anal

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
Pathology

Date 2020 Mar 25

PMID 32207861

Citations 10

Authors

Bingqu Yu

Jiayuan Chen

Chenfeng Hou

Lei Zhang

Jie Jia

Affiliations

Soon will be listed here.

Abstract

Background: Long non-coding RNA (lncRNA) H19 is involved in the carcinogenesis, progression, and metastasis of colorectal cancer (CRC). Recently, a few studies explored the relationship between lncRNA H19 gene rs2839698 polymorphism and CRC risk, but with conflicting findings.

Materials And Methods: A case-control study with 315 CRC cases and 441 controls was designed in a Chinese population. Genotyping was performed using PCR-RFLP.

Results: It was found rs2839698 polymorphism was associated with a decreased risk of CRC (AA vs GG: OR, 0.73; 95% CI, 0.54-0.98; P = .037; A vs G: OR, 0.78; 95% CI, 0.63-0.96; P = .021). Stratified analyses indicated this positive association was also significant in the non-smokers (AA vs GG: OR, 0.49; 95% CI, 0.25-0.93; P = .029), non-drinkers, those aged ≥ 60 years, and overweight individuals (BMI ≥ 24). In addition, rs2839698 polymorphism was also related to the lymph node metastasis (AA vs GG: OR, 0.43; 95% CI, 0.21-0.88; P = .019) and tumor size (AA vs GG: OR, 0.42; 95% CI, 0.20-0.88; P = .020) for patients with CRC.

Conclusion: To sum up, the lncRNA H19 gene rs2839698 polymorphism decreases the risk of CRC in Chinese individuals, especially among the non-smokers, non-drinkers, individuals aged ≥ 60 years, and overweight individuals (BMI ≥ 24). Thus, the lncRNA H19 gene rs2839698 polymorphism might be an important biomarker and diagnostic marker for predicting the susceptibility to CRC in Chinese Han population.

Citing Articles

Six polymorphisms in the lncRNA H19 gene and the risk of cancer: a systematic review and meta-analysis.

Yang M, Zhang M, Wang Q, Guo X, Geng P, Gu J BMC Cancer. 2023; 23(1):688.

PMID: 37480014 PMC: 10362596. DOI: 10.1186/s12885-023-11164-y.

Association Between rs217727 and rs2839698 H19 Polymorphisms and Obesity.

Ghafouri-Fard S, Dadyar M, Azizi S, Eslami S, Hussen B, Taheri M Biochem Genet. 2023; 62(1):229-241.

PMID: 37326896 PMC: 10901931. DOI: 10.1007/s10528-023-10418-5.

Potentials of long non-coding RNAs as biomarkers of colorectal cancer.

Lv Y, Wang Y, Zhang Z, Bao J, Su H Clin Transl Oncol. 2022; 24(9):1715-1731.

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VPS9D1-AS1 gene rs7206570 polymorphism associated with the clinical stage of colorectal cancer and binding with hsa-miR-361-3p.

Gao X, Zhang S, Wang X Hum Cell. 2022; 35(2):522-527.

PMID: 35022999 DOI: 10.1007/s13577-021-00658-1.

The influence of LncRNA H19 polymorphic variants on susceptibility to cancer: A systematic review and updated meta-analysis of 28 case-control studies.

Wang K, Zhu Z, Wang Y, Zong D, Xue P, Gu J PLoS One. 2021; 16(7):e0254943.

PMID: 34310645 PMC: 8312943. DOI: 10.1371/journal.pone.0254943.

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