Genome-wide Association Analyses in East Asians Identify New Susceptibility Loci for Colorectal Cancer

Overview

Journal Nat Genet

Specialty Genetics

Date 2012 Dec 25

PMID 23263487

Citations 118

Authors

Wei-Hua Jia

Ben Zhang

Keitaro Matsuo

Aesun Shin

Yong-Bing Xiang

Sun Ha Jee

Dong-Hyun Kim

Zefang Ren

Qiuyin Cai

Jirong Long

Jiajun Shi

Wanqing Wen

Gong Yang

Ryan J Delahanty

Bu-Tian Ji

Zhi-Zhong Pan

Fumihiko Matsuda

Yu-Tang Gao

Jae Hwan Oh

Yoon-Ok Ahn

Eun Jung Park

Hong-Lan Li

Ji Won Park

Jaeseong Jo

Jin-Young Jeong

Satoyo Hosono

Graham Casey

Ulrike Peters

Xiao-Ou Shu

Yi-Xin Zeng

Wei Zheng

Affiliations

Soon will be listed here.

Abstract

To identify new genetic factors for colorectal cancer (CRC), we conducted a genome-wide association study in east Asians. By analyzing genome-wide data in 2,098 cases and 5,749 controls, we selected 64 promising SNPs for replication in an independent set of samples, including up to 5,358 cases and 5,922 controls. We identified four SNPs with association P values of 8.58 × 10(-7) to 3.77 × 10(-10) in the combined analysis of all east Asian samples. Three of the four were replicated in a study conducted in 26,060 individuals of European descent, with combined P values of 1.22 × 10(-10) for rs647161 (5q31.1), 6.64 × 10(-9) for rs2423279 (20p12.3) and 3.06 × 10(-8) for rs10774214 (12p13.32 near the CCND2 gene), derived from meta-analysis of data from both east Asian and European-ancestry populations. This study identified three new CRC susceptibility loci and provides additional insight into the genetics and biology of CRC.

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