Additional Data Support the Role of Rs11655237 C>T in the Development of Neuroblastoma

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2019 Apr 22

PMID 31005956

Citations 9

Authors

Yong Li

Zhen-Jian Zhuo

Haiyan Zhou

Jiabin Liu

Zan Liu

Jiao Zhang

Jiwen Cheng

Suhong Li

Haixia Zhou

Rong Zhou

Jing He

Yaowang Zhao

Affiliations

Soon will be listed here.

Abstract

Neuroblastoma is the most frequently diagnosed neural tumor of childhood. Abnormal function of the long intergenic non-coding RNA (lincRNA) has been implicated in various human malignancies. Genome-wide association studies revealed the rs11655237 C>T polymorphism to be associated with the risk of neuroblastoma, though the effect was not well defined, in part due to the small sample size in our earlier study. Herein, we verified the impact of rs11655237 C>T on the risk of neuroblastoma in 700 cases and 1516 controls from six centers in China. After pooling all enrolled patients, we observed a significant association between rs11655237 C>T and risk of neuroblastoma (TT vs. CC: adjusted odds ratio [OR]=1.58, 95% confidence interval [CI]=1.06-2.35, =0.024; additive model: adjusted OR=1.20, 95% CI=1.03-1.39, =0.020; recessive model: adjusted OR=1.50, 95% CI=1.02-2.22, =0.040). Stratification analysis revealed a significant relationship between rs11655237 CT/TT and neuroblastoma risk in subgroups of males, patients whose tumor originated in the adrenal gland, and patients with clinical stage IV disease. These findings add new evidence of the importance of rs11655237 C>T to the risk of developing neuroblastoma.

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