The Utility of Stem Cells for Neural Regeneration

Overview

Journal Brain Neurosci Adv

Publisher Sage Publications

Specialty Neurology

Date 2020 Mar 14

PMID 32166173

Citations 2

Authors

Kirsty Goncalves

Stefan Przyborski

Affiliations

Soon will be listed here.

Abstract

The use of stem cells in biomedical research is an extremely active area of science. This is because they provide tools that can be used both in vivo and vitro to either replace cells lost in degenerative processes, or to model such diseases to elucidate their underlying mechanisms. This review aims to discuss the use of stem cells in terms of providing regeneration within the nervous system, which is particularly important as neurons of the central nervous system lack the ability to inherently regenerate and repair lost connections. As populations are ageing, incidence of neurodegenerative diseases are increasing, highlighting the need to better understand the regenerative capacity and many uses of stem cells in this field.

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References

Martinez-Morales P, Revilla A, Ocana I, Gonzalez C, Sainz P, McGuire D . Progress in stem cell therapy for major human neurological disorders. Stem Cell Rev Rep. 2013; 9(5):685-99. DOI: 10.1007/s12015-013-9443-6. View

Rolls A, Shechter R, Schwartz M . The bright side of the glial scar in CNS repair. Nat Rev Neurosci. 2009; 10(3):235-41. DOI: 10.1038/nrn2591. View

Przyborski S, Christie V, Hayman M, Stewart R, Horrocks G . Human embryonal carcinoma stem cells: models of embryonic development in humans. Stem Cells Dev. 2004; 13(4):400-8. DOI: 10.1089/scd.2004.13.400. View

Sharma R . iPS Cells-The Triumphs and Tribulations. Dent J (Basel). 2018; 4(2). PMC: 5851259. DOI: 10.3390/dj4020019. View

Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K . Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007; 131(5):861-72. DOI: 10.1016/j.cell.2007.11.019. View

Ylostalo J, Bartosh T, Coble K, Prockop D . Human mesenchymal stem/stromal cells cultured as spheroids are self-activated to produce prostaglandin E2 that directs stimulated macrophages into an anti-inflammatory phenotype. Stem Cells. 2012; 30(10):2283-96. PMC: 3448872. DOI: 10.1002/stem.1191. View

Melissinaki V, Gill A, Ortega I, Vamvakaki M, Ranella A, Haycock J . Direct laser writing of 3D scaffolds for neural tissue engineering applications. Biofabrication. 2011; 3(4):045005. DOI: 10.1088/1758-5082/3/4/045005. View

Barker R, Mason S, Harrower T, Swain R, Ho A, Sahakian B . The long-term safety and efficacy of bilateral transplantation of human fetal striatal tissue in patients with mild to moderate Huntington's disease. J Neurol Neurosurg Psychiatry. 2013; 84(6):657-65. PMC: 3646287. DOI: 10.1136/jnnp-2012-302441. View

Bhangra K, Busuttil F, Phillips J, Rahim A . Using Stem Cells to Grow Artificial Tissue for Peripheral Nerve Repair. Stem Cells Int. 2016; 2016:7502178. PMC: 4861803. DOI: 10.1155/2016/7502178. View

10.

Boulis N, Federici T, Glass J, Lunn J, Sakowski S, Feldman E . Translational stem cell therapy for amyotrophic lateral sclerosis. Nat Rev Neurol. 2011; 8(3):172-6. DOI: 10.1038/nrneurol.2011.191. View

11.

Brevini T, Pennarossa G, Vanelli A, Maffei S, Gandolfi F . Parthenogenesis in non-rodent species: developmental competence and differentiation plasticity. Theriogenology. 2012; 77(4):766-72. DOI: 10.1016/j.theriogenology.2011.11.010. View

12.

Lingor P, Teusch N, Schwarz K, Mueller R, Mack H, Bahr M . Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo. J Neurochem. 2007; 103(1):181-9. DOI: 10.1111/j.1471-4159.2007.04756.x. View

13.

Kovalevich J, Langford D . Considerations for the use of SH-SY5Y neuroblastoma cells in neurobiology. Methods Mol Biol. 2013; 1078:9-21. PMC: 5127451. DOI: 10.1007/978-1-62703-640-5_2. View

14.

Martello G, Smith A . The nature of embryonic stem cells. Annu Rev Cell Dev Biol. 2014; 30:647-75. DOI: 10.1146/annurev-cellbio-100913-013116. View

15.

Gu H, Yu S, Gutekunst C, Gross R, Wei L . Inhibition of the Rho signaling pathway improves neurite outgrowth and neuronal differentiation of mouse neural stem cells. Int J Physiol Pathophysiol Pharmacol. 2013; 5(1):11-20. PMC: 3601458. View

16.

Wichterle H, Lieberam I, Porter J, Jessell T . Directed differentiation of embryonic stem cells into motor neurons. Cell. 2002; 110(3):385-97. DOI: 10.1016/s0092-8674(02)00835-8. View

17.

Dent E, Gupton S, Gertler F . The growth cone cytoskeleton in axon outgrowth and guidance. Cold Spring Harb Perspect Biol. 2010; 3(3). PMC: 3039926. DOI: 10.1101/cshperspect.a001800. View

18.

Contestabile A . Amyotrophic lateral sclerosis: from research to therapeutic attempts and therapeutic perspectives. Curr Med Chem. 2011; 18(36):5655-65. DOI: 10.2174/092986711798347289. View

19.

Kaur S, McKeown S, Rashid S . Mutant SOD1 mediated pathogenesis of Amyotrophic Lateral Sclerosis. Gene. 2015; 577(2):109-18. DOI: 10.1016/j.gene.2015.11.049. View

20.

Sareen D, ORourke J, Meera P, Muhammad A, Grant S, Simpkinson M . Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion. Sci Transl Med. 2013; 5(208):208ra149. PMC: 4090945. DOI: 10.1126/scitranslmed.3007529. View