Translational Stem Cell Therapy for Amyotrophic Lateral Sclerosis

Overview

Journal Nat Rev Neurol

Specialty Neurology

Date 2011 Dec 14

PMID 22158518

Citations 39

Authors

Nicholas M Boulis

Thais Federici

Jonathan D Glass

J Simon Lunn

Stacey A Sakowski

Eva L Feldman

Affiliations

Soon will be listed here.

Abstract

Effective treatments are urgently needed for amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease characterized by the loss of motor neurons. In 2009, the FDA approved the first phase I safety trial of direct intraspinal transplantation of neural stem cells into patients with ALS, which is currently in progress. Stem cell technologies represent a promising approach for treating ALS, but several issues must be addressed when translating promising experimental ALS therapies to patients. This article highlights the key research that supports the use of stem cells as a therapy for ALS, and discusses the rationale behind and approach to the phase I trial. Completion of the trial could pave the way for continued advances in stem cell therapy for ALS and other neurodegenerative diseases.

Citing Articles

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Cellular and Noncellular Approaches for Repairing the Damaged Blood-CNS-Barrier in Amyotrophic Lateral Sclerosis.

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Therapeutic targeting of ALS pathways: Refocusing an incomplete picture.

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Stem-Cell-Based Therapy: The Celestial Weapon against Neurological Disorders.

Zayed M, Sultan S, Alsaab H, Yousof S, Alrefaei G, Alsubhi N Cells. 2022; 11(21).

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Motor neuron replacement therapy for amyotrophic lateral sclerosis.

Liu B, Li M, Zhang L, Chen Z, Lu P Neural Regen Res. 2022; 17(8):1633-1639.

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