Transcutaneous Electrical Spinal Cord Neuromodulator (TESCoN) Improves Symptoms of Overactive Bladder

Overview

Journal Front Syst Neurosci

Specialty Neurology

Date 2020 Mar 3

PMID 32116576

Citations 26

Authors

Evgeniy Kreydin

Hui Zhong

Kyle Latack

Shirley Ye

V Reggie Edgerton

Parag Gad

Affiliations

Soon will be listed here.

Abstract

New And Noteworthy: Non-Surgical modality to reduce incidence of urinary incontinence and improve neurogenic bladder symptom scores (NBSS) in individuals with neurogenic bladder due to spinal cord injury or stroke.

Citing Articles

Spinal Cord Stimulation for Functional Restoration in Spinal Cord Injury: A Narrative Review.

Li T, Chen J Cureus. 2025; 17(2):e78610.

PMID: 40062017 PMC: 11890654. DOI: 10.7759/cureus.78610.

Role of Epidural Electrode Stimulation in Three Patients with Incomplete AIS D Spinal Cord Injury.

Chen Y, Huang X, Cheng H, Wu C, Wu M, Yan L Biomedicines. 2025; 13(1).

PMID: 39857740 PMC: 11762847. DOI: 10.3390/biomedicines13010155.

Lower urinary tract dysfunction following stroke: From molecular mechanisms to clinical anatomy.

Agapiou E, Pyrgelis E, Mavridis I, Meliou M, Wimalachandra W J Biol Methods. 2025; 11(4):e99010024.

PMID: 39839087 PMC: 11744067. DOI: 10.14440/jbm.2024.0022.

Transcutaneous Spinal Stimulation Combined with Locomotor Training Improves Functional Outcomes in a Child with Cerebral Palsy: A Case Study.

Atkinson D, Barta K, Bizama F, Anderson H, Brose S, Sayenko D Children (Basel). 2025; 11(12.

PMID: 39767868 PMC: 11675040. DOI: 10.3390/children11121439.

Case report: Combined transcutaneous spinal cord stimulation and physical therapy on recovery of neurological function after spinal cord infarction.

Leon F, Rojas C, Aliseda M, Del Rio G, Monzalvo E, Pliego-Carrillo A Front Med (Lausanne). 2024; 11:1459835.

PMID: 39568740 PMC: 11576297. DOI: 10.3389/fmed.2024.1459835.

References

Weld K, Graney M, Dmochowski R . Clinical significance of detrusor sphincter dyssynergia type in patients with post-traumatic spinal cord injury. Urology. 2000; 56(4):565-8. DOI: 10.1016/s0090-4295(00)00761-5. View

Jeong S, Cho S, Oh S . Spinal cord/brain injury and the neurogenic bladder. Urol Clin North Am. 2010; 37(4):537-46. DOI: 10.1016/j.ucl.2010.06.005. View

Fragala E, Russo G, Di Rosa A, Giardina R, Privitera S, Favilla V . Association Between the Neurogenic Bladder Symptom Score and Urodynamic Examination in Multiple Sclerosis Patients With Lower Urinary Tract Dysfunction. Int Neurourol J. 2016; 19(4):272-7. PMC: 4703935. DOI: 10.5213/inj.2015.19.4.272. View

Dasgupta R, Critchley H, Dolan R, Fowler C . Changes in brain activity following sacral neuromodulation for urinary retention. J Urol. 2005; 174(6):2268-72. DOI: 10.1097/01.ju.0000181806.59363.d1. View

Hofstoetter U, Freundl B, Danner S, Krenn M, Mayr W, Binder H . Transcutaneous Spinal Cord Stimulation Induces Temporary Attenuation of Spasticity in Individuals with Spinal Cord Injury. J Neurotrauma. 2019; 37(3):481-493. DOI: 10.1089/neu.2019.6588. View

Gerasimenko Y, Sayenko D, Gad P, Liu C, Tillakaratne N, Roy R . Feed-Forwardness of Spinal Networks in Posture and Locomotion. Neuroscientist. 2017; 23(5):441-453. PMC: 5495622. DOI: 10.1177/1073858416683681. View

Hubscher C, Herrity A, Williams C, Montgomery L, Willhite A, Angeli C . Improvements in bladder, bowel and sexual outcomes following task-specific locomotor training in human spinal cord injury. PLoS One. 2018; 13(1):e0190998. PMC: 5791974. DOI: 10.1371/journal.pone.0190998. View

Stohrer M, Blok B, Castro-Diaz D, Chartier-Kastler E, Del Popolo G, Kramer G . EAU guidelines on neurogenic lower urinary tract dysfunction. Eur Urol. 2009; 56(1):81-8. DOI: 10.1016/j.eururo.2009.04.028. View

Panfili Z, Metcalf M, Griebling T . Contemporary Evaluation and Treatment of Poststroke Lower Urinary Tract Dysfunction. Urol Clin North Am. 2017; 44(3):403-414. DOI: 10.1016/j.ucl.2017.04.007. View

10.

Rath M, Vette A, Ramasubramaniam S, Li K, Burdick J, Edgerton V . Trunk Stability Enabled by Noninvasive Spinal Electrical Stimulation after Spinal Cord Injury. J Neurotrauma. 2018; 35(21):2540-2553. PMC: 6205803. DOI: 10.1089/neu.2017.5584. View

11.

Kreydin E, Zhong H, Latack K, Ye S, Edgerton V, Gad P . Transcutaneous Electrical Spinal Cord Neuromodulator (TESCoN) Improves Symptoms of Overactive Bladder. Front Syst Neurosci. 2020; 14:1. PMC: 7017715. DOI: 10.3389/fnsys.2020.00001. View

12.

Harkema S, Wang S, Angeli C, Chen Y, Boakye M, Ugiliweneza B . Normalization of Blood Pressure With Spinal Cord Epidural Stimulation After Severe Spinal Cord Injury. Front Hum Neurosci. 2018; 12:83. PMC: 5852107. DOI: 10.3389/fnhum.2018.00083. View

13.

Sayenko D, Rath M, Ferguson A, Burdick J, Havton L, Edgerton V . Self-Assisted Standing Enabled by Non-Invasive Spinal Stimulation after Spinal Cord Injury. J Neurotrauma. 2018; 36(9):1435-1450. PMC: 6482915. DOI: 10.1089/neu.2018.5956. View

14.

Peters K, Carrico D, Perez-Marrero R, Khan A, Wooldridge L, Davis G . Randomized trial of percutaneous tibial nerve stimulation versus Sham efficacy in the treatment of overactive bladder syndrome: results from the SUmiT trial. J Urol. 2010; 183(4):1438-43. DOI: 10.1016/j.juro.2009.12.036. View

15.

Phillips A, Squair J, Sayenko D, Edgerton V, Gerasimenko Y, Krassioukov A . An Autonomic Neuroprosthesis: Noninvasive Electrical Spinal Cord Stimulation Restores Autonomic Cardiovascular Function in Individuals with Spinal Cord Injury. J Neurotrauma. 2017; 35(3):446-451. PMC: 5793952. DOI: 10.1089/neu.2017.5082. View

16.

de Groat W . A neurologic basis for the overactive bladder. Urology. 1998; 50(6A Suppl):36-52; discussion 53-6. DOI: 10.1016/s0090-4295(97)00587-6. View

17.

Welk B, Lenherr S, Elliott S, Stoffel J, Presson A, Zhang C . The Neurogenic Bladder Symptom Score (NBSS): a secondary assessment of its validity, reliability among people with a spinal cord injury. Spinal Cord. 2017; 56(3):259-264. DOI: 10.1038/s41393-017-0028-0. View

18.

Gerasimenko Y, Lu D, Modaber M, Zdunowski S, Gad P, Sayenko D . Noninvasive Reactivation of Motor Descending Control after Paralysis. J Neurotrauma. 2015; 32(24):1968-80. PMC: 4677519. DOI: 10.1089/neu.2015.4008. View

19.

Anderson K . Targeting recovery: priorities of the spinal cord-injured population. J Neurotrauma. 2005; 21(10):1371-83. DOI: 10.1089/neu.2004.21.1371. View

20.

Wagner F, Mignardot J, Le Goff-Mignardot C, Demesmaeker R, Komi S, Capogrosso M . Targeted neurotechnology restores walking in humans with spinal cord injury. Nature. 2018; 563(7729):65-71. DOI: 10.1038/s41586-018-0649-2. View