Noninvasive Spinal Neuromodulation Mitigates Symptoms of Idiopathic Overactive Bladder

Overview

Journal Bioelectron Med

Date 2022 Mar 23

PMID 35317851

Authors

Hui Zhong

Emilie Liu

Priya Kohli

Laura Perez

V Reggie Edgerton

David Ginsberg

Parag Gad

Evgeniy Kreydin

Affiliations

Soon will be listed here.

Abstract

Background: Overactive bladder (OAB) affects 12 to 30% of the world's population. The accompanying urinary urgency, frequency and incontinence can have a profound effect on quality of life, leading to depression, social isolation, avoidance of sexual activity and loss of productivity. Conservative measures such as lifestyle modification and pelvic floor physical therapy are the first line of treatment for overactive bladder. Patients who fail these may go on to take medications, undergo neuromodulation or receive injection of botulinum toxin into the bladder wall. While effective, medications have side effects and suffer from poor adherence. Neuromodulation and botulinum toxin injection are also effective but are invasive and not acceptable to some patients.

Methods: We have developed a novel transcutaneous spinal cord neuromodulator (SCONE™) that delivers multifrequency electrical stimulation to the spinal cord without the need for insertion or implantation of stimulating electrodes. Previously, multifrequency transcutaneous stimulation has been demonstrated to penetrate to the spinal cord and lead to motor activation of detrusor and external urethral sphincter muscles. Here, we report on eight patients with idiopathic overactive bladder, who underwent 12 weeks of SCONE™ therapy.

Results: All patients reported statistically significant clinical improvement in multiple symptoms of overactive bladder, such as urinary urgency, frequency and urge incontinence. In addition, patients reported significant symptomatic improvements as captured by validated clinical surveys.

Conclusion: SCONE™ therapy represents the first of its kind therapy to treat symptoms of urgency, frequency and urge urinary incontinence in patients with OAB.

Trial Registration: The study was listed on clinicaltrials.gov ( NCT03753750 ).

Citing Articles

Beyond pediatrics: noninvasive spinal neuromodulation improves motor function in an adult with cerebral palsy.

Sachdeva R, Girshin K, Shirkhani Y, Gad P Bioelectron Med. 2024; 10(1):1.

PMID: 38167312 PMC: 10762938. DOI: 10.1186/s42234-023-00133-2.

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