Structural and Functional Imaging Markers for Susceptibility to Psychosis

Overview

Journal Mol Psychiatry

Specialties Molecular Biology
Psychiatry

Date 2020 Feb 19

PMID 32066828

Citations 37

Authors

Christina Andreou

Stefan Borgwardt

Affiliations

Soon will be listed here.

Abstract

The introduction of clinical criteria for the operationalization of psychosis high risk provided a basis for early detection and treatment of vulnerable individuals. However, about two-thirds of people meeting clinical high-risk (CHR) criteria will never develop a psychotic disorder. In the effort to increase prognostic precision, structural and functional neuroimaging have received growing attention as a potentially useful resource in the prediction of psychotic transition in CHR patients. The present review summarizes current research on neuroimaging biomarkers in the CHR state, with a particular focus on their prognostic utility and limitations. Large, multimodal/multicenter studies are warranted to address issues important for clinical applicability such as generalizability and replicability, standardization of clinical definitions and neuroimaging methods, and consideration of contextual factors (e.g., age, comorbidity).

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