Progressive Brain Structural Changes Mapped As Psychosis Develops in 'at Risk' Individuals

Overview

Journal Schizophr Res

Specialty Psychiatry

Date 2009 Jan 14

PMID 19138834

Citations 147

Authors

Daqiang Sun

Lisa Phillips

Dennis Velakoulis

Alison Yung

Patrick D McGorry

Stephen J Wood

Theo G M van Erp

Paul M Thompson

Arthur W Toga

Tyrone D Cannon

Christos Pantelis

Affiliations

Soon will be listed here.

Abstract

Background: Schizophrenia and related psychoses are associated with brain structural abnormalities. Recent findings in 'at risk' populations have identified progressive changes in various brain regions preceding illness onset, while changes especially in prefrontal and superior temporal regions have been demonstrated in first-episode schizophrenia patients. However, the timing of the cortical changes and their regional extent, relative to the emergence of psychosis, has not been clarified. We followed individuals at high-risk for psychosis to determine whether structural changes in the cerebral cortex occur with the onset of psychosis. We hypothesized that progressive volume loss occurs in prefrontal regions during the transition to psychosis.

Methods: 35 individuals at ultra-high risk (UHR) for developing psychosis, of whom 12 experienced psychotic onset by 1-year follow-up ('converters'), participated in a longitudinal structural MRI study. Baseline and follow-up T1-weighted MR images were acquired and longitudinal brain surface contractions were assessed using Cortical Pattern Matching.

Results: Significantly greater brain contraction was found in the right prefrontal region in the 'converters' compared with UHR cases who did not develop psychosis ('non-converters').

Conclusions: These findings show cortical volume loss is associated with the onset of psychosis, indicating ongoing pathological processes during the transition stage to illness. The prefrontal volume loss is in line with structural and functional abnormalities in schizophrenia, suggesting a critical role for this change in the development of psychosis.

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