How Will Developmental Neuroimaging Contribute to the Prediction of Neurodevelopmental or Psychiatric Disorders? Challenges and Opportunities

Overview

Journal Dev Cogn Neurosci

Publisher Elsevier

Specialties Neurology
Psychiatry

Date 2024 Dec 19

PMID 39700912

Authors

Koraly Perez-Edgar

Mary Dozier

Rebecca Saxe

Katherine E MacDuffie

Affiliations

Soon will be listed here.

Abstract

Successful developmental neuroimaging efforts require interdisciplinary expertise to ground scientific questions in knowledge of human development, modify and create technologies and data processing pipelines suited to the young brain, and ensure research procedures meet the needs and protect the interests of young children and their caregivers. This paper brings together four interdisciplinary perspectives to tackle a set of questions that are central for the field to address as we imagine a future role for developmental neuroimaging in the prediction of neurodevelopmental or psychiatric disorders: 1) How do we generate a strong evidence base for causality and clinical relevance? 2) How do we ensure the integrity of the data and support fair and wide access? 3) How can these technologies be implemented in the clinic? 4) What are the ethical obligations for neuroimaging researchers working with infants and young children?

References

Largent E, Lynch H . Paying Research Participants: The Outsized Influence of "Undue Influence". IRB. 2017; 39(4):1-9. PMC: 5640154. View

Debnath R, Tang A, Zeanah C, Nelson C, Fox N . The long-term effects of institutional rearing, foster care intervention and disruptions in care on brain electrical activity in adolescence. Dev Sci. 2019; 23(1):e12872. PMC: 6884653. DOI: 10.1111/desc.12872. View

Bick J, Palmwood E, Zajac L, Simons R, Dozier M . Early Parenting Intervention and Adverse Family Environments Affect Neural Function in Middle Childhood. Biol Psychiatry. 2018; 85(4):326-335. PMC: 6373871. DOI: 10.1016/j.biopsych.2018.09.020. View

Pfeifer J, Allen N . The audacity of specificity: Moving adolescent developmental neuroscience towards more powerful scientific paradigms and translatable models. Dev Cogn Neurosci. 2016; 17:131-7. PMC: 4826651. DOI: 10.1016/j.dcn.2015.12.012. View

Lombardo M, Chakrabarti B, Bullmore E, Baron-Cohen S . Specialization of right temporo-parietal junction for mentalizing and its relation to social impairments in autism. Neuroimage. 2011; 56(3):1832-8. DOI: 10.1016/j.neuroimage.2011.02.067. View

Valadez E, Tottenham N, Tabachnick A, Dozier M . Early Parenting Intervention Effects on Brain Responses to Maternal Cues Among High-Risk Children. Am J Psychiatry. 2020; 177(9):818-826. PMC: 7716800. DOI: 10.1176/appi.ajp.2020.20010011. View

Ostlund B, Myruski S, Buss K, Perez-Edgar K . The centrality of temperament to the research domain criteria (RDoC): The earliest building blocks of psychopathology. Dev Psychopathol. 2021; 33(5):1584-1598. PMC: 10039756. DOI: 10.1017/S0954579421000511. View

Zeanah C, Fox N, Nelson C . The Bucharest Early Intervention Project: case study in the ethics of mental health research. J Nerv Ment Dis. 2012; 200(3):243-7. PMC: 4158102. DOI: 10.1097/NMD.0b013e318247d275. View

Pfeifer J, Weston S . Developmental cognitive neuroscience initiatives for advancements in methodological approaches: Registered Reports and Next-Generation Tools. Dev Cogn Neurosci. 2020; 44:100755. PMC: 7374242. DOI: 10.1016/j.dcn.2020.100755. View

10.

Morrison A, Pyle M, Maughan D, Johns L, Freeman D, Broome M . Antipsychotic medication versus psychological intervention versus a combination of both in adolescents with first-episode psychosis (MAPS): a multicentre, three-arm, randomised controlled pilot and feasibility study. Lancet Psychiatry. 2020; 7(9):788-800. PMC: 7606914. DOI: 10.1016/S2215-0366(20)30248-0. View

11.

Andreou C, Borgwardt S . Structural and functional imaging markers for susceptibility to psychosis. Mol Psychiatry. 2020; 25(11):2773-2785. PMC: 7577836. DOI: 10.1038/s41380-020-0679-7. View

12.

Ellis R . Questionable Research Practices, Low Statistical Power, and Other Obstacles to Replicability: Why Preclinical Neuroscience Research Would Benefit from Registered Reports. eNeuro. 2022; 9(4). PMC: 9351632. DOI: 10.1523/ENEURO.0017-22.2022. View

13.

Spann M, Scheinost D . Applying fetal, infant, and toddler (FIT) neuroimaging to understand mental health. Neuropsychopharmacology. 2024; 50(1):310-311. PMC: 11525938. DOI: 10.1038/s41386-024-01957-5. View

14.

Smith J, Wakschlag L, Krogh-Jespersen S, Walkup J, Wilson M, Dishion T . Dysregulated Irritability as a Window on Young Children's Psychiatric Risk: Transdiagnostic Effects via the Family Check-Up. Dev Psychopathol. 2019; 31(5):1887-1899. PMC: 7279524. DOI: 10.1017/S0954579419000816. View

15.

Yarkoni T . The generalizability crisis. Behav Brain Sci. 2020; 45:e1. PMC: 10681374. DOI: 10.1017/S0140525X20001685. View

16.

Sheridan M, Fox N, Zeanah C, McLaughlin K, Nelson 3rd C . Variation in neural development as a result of exposure to institutionalization early in childhood. Proc Natl Acad Sci U S A. 2012; 109(32):12927-32. PMC: 3420193. DOI: 10.1073/pnas.1200041109. View

17.

Sheridan M, Mukerji C, Wade M, Humphreys K, Garrisi K, Goel S . Early deprivation alters structural brain development from middle childhood to adolescence. Sci Adv. 2022; 8(40):eabn4316. PMC: 9544316. DOI: 10.1126/sciadv.abn4316. View

18.

Whitehouse A, Varcin K, Pillar S, Billingham W, Alvares G, Barbaro J . Effect of Preemptive Intervention on Developmental Outcomes Among Infants Showing Early Signs of Autism: A Randomized Clinical Trial of Outcomes to Diagnosis. JAMA Pediatr. 2021; 175(11):e213298. PMC: 8453361. DOI: 10.1001/jamapediatrics.2021.3298. View

19.

Richardson H, Lisandrelli G, Riobueno-Naylor A, Saxe R . Development of the social brain from age three to twelve years. Nat Commun. 2018; 9(1):1027. PMC: 5847587. DOI: 10.1038/s41467-018-03399-2. View

20.

Korom M, Valadez E, Tottenham N, Dozier M, Spielberg J . Preliminary examination of the effects of an early parenting intervention on amygdala-orbitofrontal cortex resting-state functional connectivity among high-risk children: A randomized clinical trial. Dev Psychopathol. 2024; 37(1):384-392. PMC: 11260902. DOI: 10.1017/S0954579423001669. View