A Genetic Pathway for the Development of the Caenorhabditis Elegans HSN Motor Neurons

Overview

Journal Nature

Specialty Science

Date 1988 Dec 15

PMID 3200316

Citations 150

Authors

C Desai

G Garriga

S L McIntire

H R Horvitz

Affiliations

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Abstract

Thirty-five genes define a pathway for the development of the hermaphrodite-specific neurons (HSNs) in Caenorhabditis elegans. Some of these genes affect only one HSN trait, demonstrating that HSN migration, axonal outgrowth and serotonin expression are mutually independent events in HSN development; others, some of which are regulatory, affect multiple HSN traits. Nearly all are pleiotropic, revealing that the genes specifying HSN development also function in the development of other cell types.

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