Atypical TGF-β Signaling Controls Neuronal Guidance in

Overview

Journal iScience

Publisher Cell Press

Date 2022 Feb 11

PMID 35146399

Authors

Oguzhan Baltaci

Mikael Egebjerg Pedersen

Tessa Sherry

Ava Handley

Goda Snieckute

Wei Cao

Matilda Haas

Stuart Archer

Roger Pocock

Affiliations

Soon will be listed here.

Abstract

Coordinated expression of cell adhesion and signaling molecules is crucial for brain development. Here, we report that the transforming growth factor β (TGF-β) type I receptor SMA-6 (small-6) acts independently of its cognate TGF-β type II receptor DAF-4 (dauer formation-defective-4) to control neuronal guidance. SMA-6 directs neuronal development from the hypodermis through interactions with three, orphan, TGF-β ligands. Intracellular signaling downstream of SMA-6 limits expression of NLR-1, an essential Neurexin-like cell adhesion receptor, to enable neuronal guidance. Together, our data identify an atypical TGF-β-mediated regulatory mechanism to ensure correct neuronal development.

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