A Serotonergic Circuit Regulates Aversive Associative Learning Under Mitochondrial Stress in

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2022 Mar 7

PMID 35254908

Authors

Yueh-Chen Chiang

Chien-Po Liao

Chun-Liang Pan

Affiliations

Soon will be listed here.

Abstract

SignificancePhysiological stress triggers avoidance behavior, allowing the animals to stay away from potential threats and optimize their chance of survival. Mitochondrial disruption, a common physiological stress in diverse species, induces the nematode to avoid non-pathogenic bacteria through a serotonergic neuronal circuit. We find that distinct neurons, communicated through serotonin and a specific serotonin receptor, are required for the formation and retrieval of this learned aversive behavior. This learned avoidance behavior is associated with increased serotonin synthesis, altered neuronal response property, and reprogramming of locomotion patterns. The circuit and neuromodulatory mechanisms described here offer important insights for stress-induced avoidance behavior.

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