The P75 Receptor Transduces the Signal from Myelin-associated Glycoprotein to Rho

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2002 May 16

PMID 12011108

Citations 125

Authors

Toshihide Yamashita

Haruhisa Higuchi

Masaya Tohyama

Affiliations

Soon will be listed here.

Abstract

Myelin-associated glycoprotein (MAG) is a potent inhibitor of neurite outgrowth from a variety of neurons. The receptor for MAG or signals that elicit morphological changes in neurons remained to be established. Here we show that the neurotrophin receptor p75 (p75(NTR)) is the signal transducing element for MAG. Adult dorsal root ganglion neurons or postnatal cerebellar neurons from mice carrying a mutation in the p75(NTR) gene are insensitive to MAG with regard to neurite outgrowth. MAG activates small GTPase RhoA, leading to retarded outgrowth when p75(NTR)) is present. Colocalization of p75(NTR) and MAG binding is seen in neurons. Ganglioside GT1b, which is one of the binding partners of MAG, specifically associates with p75(NTR). Thus, p75(NTR) and GT1b may form a receptor complex for MAG to transmit the inhibitory signals in neurons.

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