Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2020 Jan 23

PMID 31963586

Citations 26

Authors

Ahmad Omar Noor

Diena Mohammedallam Almasri

Alaa Abdullah Bagalagel

Hossam Mohamed Abdallah

Shaimaa Gamal Abdallah Mohamed

Gamal Abdallah Mohamed

Sabrin Ragab Mohamed Ibrahim

Affiliations

Soon will be listed here.

Abstract

Recently, the metabolites separated from endophytes have attracted significant attention, as many of them have a unique structure and appealing pharmacological and biological potentials. Isocoumarins represent one of the most interesting classes of metabolites, which are coumarins isomers with a reversed lactone moiety. They are produced by plants, microbes, marine organisms, bacteria, insects, liverworts, and fungi and possessed a wide array of bioactivities. This review gives an overview of isocoumarins derivatives from endophytic fungi and their source, isolation, structural characterization, biosynthesis, and bioactivities, concentrating on the period from 2000 to 2019. Overall, 307 metabolites and more than 120 references are conferred. This is the first review on these multi-facetted metabolites from endophytic fungi.

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