Pyranone Derivatives With Antitumor Activities, From the Endophytic Fungus Sp. YN02-P-3

Overview

Journal Front Chem

Specialty Chemistry

Date 2022 Jul 25

PMID 35873041

Authors

Chong Yu

Yin Nian

Huanhua Chen

Shuwen Liang

Mengyang Sun

Yuehu Pei

Haifeng Wang

Affiliations

Soon will be listed here.

Abstract

Two new pyranone derivatives phomapyrone A (2) and phomapyrone B (3), one new coumarin 11 13-(+)-phomacumarin A (1), three known pyranones (4-6), together with three known amide alkaloids fuscoatramides A-C (7-9), as well as 9 11-(+)-ascosalitoxin (10) were isolated from the endophytic fungus sp. YN02-P-3, which was isolated from the healthy leaf tissue of a Paulownia tree in Yunnan Province, China. Their structures were elucidated using extensive NMR spectroscopic and HRESIMS data and by comparing the information with literature data. In addition, all compounds were tested for their cytotoxicity activity against human tumor cell lines, and the results showed that new compounds 1-3 showed moderate inhibitory activity against the HL-60 cell line with IC values of 31.02, 34.62, and 27.90 M, respectively.

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