Antimalarial Dihydroisocoumarins Produced by Geotrichum Sp., an Endophytic Fungus of Crassocephalum Crepidioides

Overview

Journal J Nat Prod

Date 2003 May 24

PMID 12762815

Citations 12

Authors

Palangpon Kongsaeree

Samran Prabpai

Nongluksna Sriubolmas

Chanika Vongvein

Suthep Wiyakrutta

Affiliations

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Abstract

Three novel dihydroisocoumarin derivatives (1-3) with antimalarial, antituberculous, and antifungal activities have been isolated by bioassay-guided fractionation from an endophytic fungus, Geotrichum sp., collected from Crassocephalum crepidioides. Structures were established as 7-butyl-6,8-dihydroxy-3(R)-pent-11-enylisochroman-1-one (1), 7-but-15-enyl-6,8-dihydroxy-3(R)-pent-11-enylisochroman-1-one (2), and 7-butyl-6,8-dihydroxy-3(R)-pentylisochroman-1-one (3) using spectroscopic data.

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