Palmitoylation of BMPR1a Regulates Neural Stem Cell Fate

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2019 Nov 28

PMID 31772009

Citations 16

Authors

Thomas Wegleiter

Kilian Buthey

Daniel Gonzalez-Bohorquez

Martina Hruzova

Muhammad Khadeesh Bin Imtiaz

Andrin Abegg

Iliana Mebert

Adriano Molteni

Dominik Kollegger

Pawel Pelczar

Sebastian Jessberger

Affiliations

Soon will be listed here.

Abstract

Neural stem cells (NSCs) generate neurons and glial cells throughout embryonic and postnatal brain development. The role of S-palmitoylation (also referred to as S-acylation), a reversible posttranslational lipid modification of proteins, in regulating the fate and activity of NSCs remains largely unknown. We used an unbiased screening approach to identify proteins that are S-acylated in mouse NSCs and showed that bone morphogenic protein receptor 1a (BMPR1a), a core mediator of BMP signaling, is palmitoylated. Genetic manipulation of S-acylated sites affects the localization and trafficking of BMPR1a and leads to altered BMP signaling. Strikingly, defective palmitoylation of BMPR1a modulates NSC function within the mouse brain, resulting in enhanced oligodendrogenesis. Thus, we identified a mechanism regulating the behavior of NSCs and provided the framework to characterize dynamic posttranslational lipid modifications of proteins in the context of NSC biology.

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