A Not-So-Ancient Grease History: Click Chemistry and Protein Lipid Modifications

Overview

Journal Chem Rev

Publisher American Chemical Society

Specialty Chemistry

Date 2021 Apr 6

PMID 33821625

Citations 25

Authors

Kiall F Suazo

Keun-Young Park

Mark D Distefano

Affiliations

Soon will be listed here.

Abstract

Protein lipid modification involves the attachment of hydrophobic groups to proteins via ester, thioester, amide, or thioether linkages. In this review, the specific click chemical reactions that have been employed to study protein lipid modification and their use for specific labeling applications are first described. This is followed by an introduction to the different types of protein lipid modifications that occur in biology. Next, the roles of click chemistry in elucidating specific biological features including the identification of lipid-modified proteins, studies of their regulation, and their role in diseases are presented. A description of the use of protein-lipid modifying enzymes for specific labeling applications including protein immobilization, fluorescent labeling, nanostructure assembly, and the construction of protein-drug conjugates is presented next. Concluding remarks and future directions are presented in the final section.

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