Mucosal-associated Invariant T Cells and Disease

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2019 Jul 17

PMID 31308521

Citations 128

Authors

Amine Toubal

Isabelle Nel

Sophie Lotersztajn

Agnes Lehuen

Affiliations

Soon will be listed here.

Abstract

Mucosal-associated invariant T (MAIT) cells are unique innate-like T cells that bridge innate and adaptive immunity. They are activated by conserved bacterial ligands derived from vitamin B biosynthesis and have important roles in defence against bacterial and viral infections. However, they can also have various deleterious and protective functions in autoimmune, inflammatory and metabolic diseases. MAIT cell involvement in a large spectrum of pathological conditions makes them attractive targets for potential therapeutic approaches.

Citing Articles

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