Insights into the Tissue Repair Features of MAIT Cells

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2024 Aug 1

PMID 39086492

Authors

Mengge Gao

Xiaosu Zhao

Affiliations

Soon will be listed here.

Abstract

Mucosa-associated invariant T (MAIT) cells are a subset of innate-like non-conventional T cells characterized by multifunctionality. In addition to their well-recognized antimicrobial activity, increasing attention is being drawn towards their roles in tissue homeostasis and repair. However, the precise mechanisms underlying these functions remain incompletely understood and are still subject to ongoing exploration. Currently, it appears that the tissue localization of MAIT cells and the nature of the diseases or stimuli, whether acute or chronic, may induce a dynamic interplay between their pro-inflammatory and anti-inflammatory, or pathogenic and reparative functions. Therefore, elucidating the conditions and mechanisms of MAIT cells' reparative functions is crucial for fully maximizing their protective effects and advancing future MAIT-related therapies. In this review, we will comprehensively discuss the establishment and potential mechanisms of their tissue repair functions as well as the translational application prospects and current challenges in this field.

Citing Articles

Biological functions and therapeutic applications of human mucosal-associated invariant T cells.

Fang Y, Chen Y, Niu S, Lyu Z, Tian Y, Shen X J Biomed Sci. 2025; 32(1):32.

PMID: 40025566 PMC: 11871619. DOI: 10.1186/s12929-025-01125-x.

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