Role of Mucosal-associated Invariant T Cells Dynamics in Pathogenesis of Sjögren Syndrome

Overview

Journal Sci Rep

Specialty Science

Date 2024 Jul 26

PMID 39060324

Authors

Jeanne Chauffier

Henri Berger de Gallardo

Mathieu F Chevalier

Aicha Kante

Marion Lambert

Xavier Cabrol

Elisa Aldersons

Stephane Mouly

Karine Champion

Blanca Amador-Borrero

Ruxandra Burlacu

William Bigot

Homa Adle-Biassete

Rachid Kaci

Aurelie Selvanadin

Martine Cohen-Solal

Amelie Coudert

Sophie Caillat-Zucman

Damien Sene

Cloe Comarmond

Affiliations

Soon will be listed here.

Abstract

Sjögren syndrome (SS) is an autoimmune disease characterized by chronic inflammatory infiltrates in the salivary and lacrimal glands. Mucosal-associated invariant T (MAIT) cells are a subset of innate-like T-cells, predominantly found in mucosal tissues with crucial role in epithelial homeostasis. Thus, MAIT cells may be implicated in mucosal alterations of SS patients. Activation markers, inflammatory and cytotoxic cytokines were examined in 23 SS patients and compared to 23 healthy controls (HC). Tissular MAIT cells in salivary gland (SG) biopsies were also analyzed. Circulating MAIT cells were decreased in SS patients with a higher expression of CD69 and a higher CD4/CD8 ratio of MAIT cells. MAIT cells showed a higher production of IFNγ, TNFα and GzB in SS compare to HC. Tissular MAIT cells were present within inflamed SG of SS patients, while they were absent in SG of HC. Overall, circulating MAIT cells are decreased in the peripheral blood of SS albeit producing higher amounts of IFNγ, TNFα, and GzB. Tissular MAIT cells are detected in salivary glands from SS with a proinflammatory tissular cytokine environment. MAIT cells with abnormal phenotype, functions and tissular homeostasis may contribute to epithelial damage in SS.

References

Ioannidis M, Cerundolo V, Salio M . The Immune Modulating Properties of Mucosal-Associated Invariant T Cells. Front Immunol. 2020; 11:1556. PMC: 7438542. DOI: 10.3389/fimmu.2020.01556. View

Li J, Reantragoon R, Kostenko L, Corbett A, Varigos G, Carbone F . The frequency of mucosal-associated invariant T cells is selectively increased in dermatitis herpetiformis. Australas J Dermatol. 2016; 58(3):200-204. DOI: 10.1111/ajd.12456. View

Hinks T, Zhou X, Staples K, Dimitrov B, Manta A, Petrossian T . Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms. J Allergy Clin Immunol. 2015; 136(2):323-33. PMC: 4534770. DOI: 10.1016/j.jaci.2015.01.014. View

Le Bourhis L, Martin E, Peguillet I, Guihot A, Froux N, Core M . Antimicrobial activity of mucosal-associated invariant T cells. Nat Immunol. 2010; 11(8):701-8. DOI: 10.1038/ni.1890. View

Talvard-Balland N, Lambert M, Chevalier M, Minet N, Salou M, Tourret M . Human MAIT cells inhibit alloreactive T cell responses and protect against acute graft-versus-host disease. JCI Insight. 2024; 9(5). PMC: 11143928. DOI: 10.1172/jci.insight.166310. View

Wang J, Macardle C, Weedon H, Beroukas D, Banovic T . Mucosal-associated invariant T cells are reduced and functionally immature in the peripheral blood of primary Sjögren's syndrome patients. Eur J Immunol. 2016; 46(10):2444-2453. DOI: 10.1002/eji.201646300. View

Trutschel D, Bost P, Mariette X, Bondet V, Llibre A, Posseme C . Variability of Primary Sjögren's Syndrome Is Driven by Interferon-α and Interferon-α Blood Levels Are Associated With the Class II HLA-DQ Locus. Arthritis Rheumatol. 2022; 74(12):1991-2002. PMC: 10092541. DOI: 10.1002/art.42265. View

Li Y, Du J, Wei W . Emerging Roles of Mucosal-Associated Invariant T Cells in Rheumatology. Front Immunol. 2022; 13:819992. PMC: 8934402. DOI: 10.3389/fimmu.2022.819992. View

Salou M, Nicol B, Garcia A, Baron D, Michel L, Elong-Ngono A . Neuropathologic, phenotypic and functional analyses of Mucosal Associated Invariant T cells in Multiple Sclerosis. Clin Immunol. 2016; 166-167:1-11. DOI: 10.1016/j.clim.2016.03.014. View

10.

Ghesquiere T, Ciudad M, Ramon A, Greigert H, Gerard C, Cladiere C . Mucosal-associated invariant T cells in Giant Cell Arteritis. J Autoimmun. 2021; 121:102652. DOI: 10.1016/j.jaut.2021.102652. View

11.

Ebert L, McColl S . Up-regulation of CCR5 and CCR6 on distinct subpopulations of antigen-activated CD4+ T lymphocytes. J Immunol. 2001; 168(1):65-72. DOI: 10.4049/jimmunol.168.1.65. View

12.

Shiboski C, Shiboski S, Seror R, Criswell L, Labetoulle M, Lietman T . 2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjögren's syndrome: A consensus and data-driven methodology involving three international patient cohorts. Ann Rheum Dis. 2016; 76(1):9-16. DOI: 10.1136/annrheumdis-2016-210571. View

13.

Pavlovic M, Gross C, Chili C, Secher T, Treiner E . MAIT Cells Display a Specific Response to Type 1 IFN Underlying the Adjuvant Effect of TLR7/8 Ligands. Front Immunol. 2020; 11:2097. PMC: 7509539. DOI: 10.3389/fimmu.2020.02097. View

14.

Guggino G, Di Liberto D, Lo Pizzo M, Saieva L, Alessandro R, Dieli F . IL-17 polarization of MAIT cells is derived from the activation of two different pathways. Eur J Immunol. 2017; 47(11):2002-2003. DOI: 10.1002/eji.201747140. View

15.

Chiba A, Tamura N, Yoshikiyo K, Murayama G, Kitagaichi M, Yamaji K . Activation status of mucosal-associated invariant T cells reflects disease activity and pathology of systemic lupus erythematosus. Arthritis Res Ther. 2017; 19(1):58. PMC: 5348792. DOI: 10.1186/s13075-017-1257-5. View

16.

Cho Y, Kee S, Kim T, Jin H, Kim M, Jung H . Mucosal-associated invariant T cell deficiency in systemic lupus erythematosus. J Immunol. 2014; 193(8):3891-901. DOI: 10.4049/jimmunol.1302701. View

17.

Legoux F, Salou M, Lantz O . MAIT Cell Development and Functions: the Microbial Connection. Immunity. 2020; 53(4):710-723. DOI: 10.1016/j.immuni.2020.09.009. View

18.

Ye L, Pan J, Pasha M, Shen X, DSouza S, Fung I . Mucosal-associated invariant T cells restrict allergic airway inflammation. J Allergy Clin Immunol. 2019; 145(5):1469-1473.e4. PMC: 7214121. DOI: 10.1016/j.jaci.2019.12.891. View

19.

Bugaut H, El Morr Y, Mestdagh M, Darbois A, Paiva R, Salou M . A conserved transcriptional program for MAIT cells across mammalian evolution. J Exp Med. 2023; 221(2). PMC: 10733631. DOI: 10.1084/jem.20231487. View

20.

Daniels T, Cox D, Shiboski C, Schiodt M, Wu A, Lanfranchi H . Associations between salivary gland histopathologic diagnoses and phenotypic features of Sjögren's syndrome among 1,726 registry participants. Arthritis Rheum. 2011; 63(7):2021-30. PMC: 3128201. DOI: 10.1002/art.30381. View