New Frontiers in IVF: MtDNA and Autologous Germline Mitochondrial Energy Transfer

Overview

Journal Reprod Biol Endocrinol

Publisher Biomed Central

Specialties Endocrinology
Reproductive Medicine

Date 2019 Jul 14

PMID 31299996

Citations 19

Authors

Mauro Cozzolino

Diego Marin

Giovanni Sisti

Affiliations

Soon will be listed here.

Abstract

Many infertility specialists support the existence of a relationship between the levels of mitochondrial DNA and the quality of the blastocysts. Despite the extensive use of pre-implantation genetic testing for aneuploidy, a significant percentage of euploid embryos do not implant even though the endometrium is normal. Mitochondrial DNA may be used as a new test in evaluating embryonic vitality.Ovarian aging leads to a decrease in the quantity and quality of oocytes and aged oocytes have a reduced number of mitochondria. Mitochondria are the energy factories of the cells and their lacked could leads to lower fertilization rates and poor embryonic development. Various strategies have been tested to increase the mitochondria quantity and thus improve the quality of oocytes used in in vitro fertilization. Results of ovarian rejuvenation techniques such as autologous mitochondrial transplantation have been controversial. In this review, we describe the state of the art concerning the use of mitochondrial DNA and autologous mitochondrial transplantation as new possibilities to increase success in vitro fertilization.

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References

Brown W, George Jr M, Wilson A . Rapid evolution of animal mitochondrial DNA. Proc Natl Acad Sci U S A. 1979; 76(4):1967-71. PMC: 383514. DOI: 10.1073/pnas.76.4.1967. View

Motta P, Nottola S, Makabe S, Heyn R . Mitochondrial morphology in human fetal and adult female germ cells. Hum Reprod. 2000; 15 Suppl 2:129-47. DOI: 10.1093/humrep/15.suppl_2.129. View

Van Blerkom J, Davis P, Alexander S . Differential mitochondrial distribution in human pronuclear embryos leads to disproportionate inheritance between blastomeres: relationship to microtubular organization, ATP content and competence. Hum Reprod. 2000; 15(12):2621-33. DOI: 10.1093/humrep/15.12.2621. View

Barritt J, Brenner C, Malter H, Cohen J . Mitochondria in human offspring derived from ooplasmic transplantation. Hum Reprod. 2001; 16(3):513-6. DOI: 10.1093/humrep/16.3.513. View

Reynier P, May-Panloup P, Chretien M, Morgan C, Jean M, Savagner F . Mitochondrial DNA content affects the fertilizability of human oocytes. Mol Hum Reprod. 2001; 7(5):425-9. DOI: 10.1093/molehr/7.5.425. View

Gray M, Burger G, Lang B . The origin and early evolution of mitochondria. Genome Biol. 2001; 2(6):REVIEWS1018. PMC: 138944. DOI: 10.1186/gb-2001-2-6-reviews1018. View

Yesodi V, Yaron Y, Lessing J, Amit A, Ben-Yosef D . The mitochondrial DNA mutation (deltamtDNA5286) in human oocytes: correlation with age and IVF outcome. J Assist Reprod Genet. 2002; 19(2):60-6. PMC: 3468229. DOI: 10.1023/a:1014439529813. View

Dunson D, Colombo B, Baird D . Changes with age in the level and duration of fertility in the menstrual cycle. Hum Reprod. 2002; 17(5):1399-403. DOI: 10.1093/humrep/17.5.1399. View

Johnson J, Canning J, Kaneko T, Pru J, Tilly J . Germline stem cells and follicular renewal in the postnatal mammalian ovary. Nature. 2004; 428(6979):145-50. DOI: 10.1038/nature02316. View

10.

May-Panloup P, Chretien M, Jacques C, Vasseur C, Malthiery Y, Reynier P . Low oocyte mitochondrial DNA content in ovarian insufficiency. Hum Reprod. 2004; 20(3):593-7. DOI: 10.1093/humrep/deh667. View

11.

Johnson J, Bagley J, Skaznik-Wikiel M, Lee H, Adams G, Niikura Y . Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood. Cell. 2005; 122(2):303-15. PMC: 11771209. DOI: 10.1016/j.cell.2005.06.031. View

12.

Chan C, Liu V, Lau E, Yeung W, Ng E, Ho P . Mitochondrial DNA content and 4977 bp deletion in unfertilized oocytes. Mol Hum Reprod. 2006; 11(12):843-6. DOI: 10.1093/molehr/gah243. View

13.

El Shourbagy S, Spikings E, Freitas M, St John J . Mitochondria directly influence fertilisation outcome in the pig. Reproduction. 2006; 131(2):233-45. DOI: 10.1530/rep.1.00551. View

14.

Almeida Santos T, El Shourbagy S, St John J . Mitochondrial content reflects oocyte variability and fertilization outcome. Fertil Steril. 2006; 85(3):584-91. DOI: 10.1016/j.fertnstert.2005.09.017. View

15.

Navot D, Bergh P, Williams M, Garrisi G, Guzman I, Sandler B . Poor oocyte quality rather than implantation failure as a cause of age-related decline in female fertility. Lancet. 1991; 337(8754):1375-7. DOI: 10.1016/0140-6736(91)93060-m. View

16.

Baxter Bendus A, Mayer J, Shipley S, Catherino W . Interobserver and intraobserver variation in day 3 embryo grading. Fertil Steril. 2006; 86(6):1608-15. DOI: 10.1016/j.fertnstert.2006.05.037. View

17.

Satoh M, Kuroiwa T . Organization of multiple nucleoids and DNA molecules in mitochondria of a human cell. Exp Cell Res. 1991; 196(1):137-40. DOI: 10.1016/0014-4827(91)90467-9. View

18.

Dumollard R, Duchen M, Carroll J . The role of mitochondrial function in the oocyte and embryo. Curr Top Dev Biol. 2007; 77:21-49. DOI: 10.1016/S0070-2153(06)77002-8. View

19.

Cao L, Shitara H, Horii T, Nagao Y, Imai H, Abe K . The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells. Nat Genet. 2007; 39(3):386-90. DOI: 10.1038/ng1970. View

20.

Kujoth G, Bradshaw P, Haroon S, Prolla T . The role of mitochondrial DNA mutations in mammalian aging. PLoS Genet. 2007; 3(2):e24. PMC: 1802824. DOI: 10.1371/journal.pgen.0030024. View