Ovarian Aging: Energy Metabolism of Oocytes

Overview

Journal J Ovarian Res

Publisher Biomed Central

Specialties Gynecology & Obstetrics
Reproductive Medicine

Date 2024 Jun 1

PMID 38822408

Authors

Shenglan Bao

Tailang Yin

Su Liu

Affiliations

Soon will be listed here.

Abstract

In women who are getting older, the quantity and quality of their follicles or oocytes and decline. This is characterized by decreased ovarian reserve function (DOR), fewer remaining oocytes, and lower quality oocytes. As more women choose to delay childbirth, the decline in fertility associated with age has become a significant concern for modern women. The decline in oocyte quality is a key indicator of ovarian aging. Many studies suggest that age-related changes in oocyte energy metabolism may impact oocyte quality. Changes in oocyte energy metabolism affect adenosine 5'-triphosphate (ATP) production, but how related products and proteins influence oocyte quality remains largely unknown. This review focuses on oocyte metabolism in age-related ovarian aging and its potential impact on oocyte quality, as well as therapeutic strategies that may partially influence oocyte metabolism. This research aims to enhance our understanding of age-related changes in oocyte energy metabolism, and the identification of biomarkers and treatment methods.

Citing Articles

Effects of 100 IU versus 150 IU hCG supplementation on oocyte and embryo quality in patients aged ≥ 35 years: a propensity score-matched analysis.

Huong N, Thuy T, Anh P, Long H, Thang L, Ngoc V Int J Med Sci. 2025; 22(4):982-989.

PMID: 39991766 PMC: 11843143. DOI: 10.7150/ijms.106965.

Melatonin supplementation attenuates cuproptosis and ferroptosis in aging cumulus and granulosa cells: potential for improving IVF outcomes in advanced maternal age.

Tsui K, Li C, Lin L Reprod Biol Endocrinol. 2024; 22(1):138.

PMID: 39516964 PMC: 11545199. DOI: 10.1186/s12958-024-01311-w.

Causal association between telomere length and female reproductive endocrine diseases: a univariable and multivariable Mendelian randomization analysis.

Yang Q, Zhang J, Fan Z J Ovarian Res. 2024; 17(1):146.

PMID: 39010148 PMC: 11247788. DOI: 10.1186/s13048-024-01466-5.

References

Cordoba-Jover B, Ribera J, Portoles I, Lecue E, Rodriguez-Vita J, Perez-Sisques L . Tcf20 deficiency is associated with increased liver fibrogenesis and alterations in mitochondrial metabolism in mice and humans. Liver Int. 2023; 43(8):1822-1836. DOI: 10.1111/liv.15640. View

Kinnear H, Tomaszewski C, Chang A, Moravek M, Xu M, Padmanabhan V . The ovarian stroma as a new frontier. Reproduction. 2020; 160(3):R25-R39. PMC: 7453977. DOI: 10.1530/REP-19-0501. View

Oseikria M, Elis S, Maillard V, Corbin E, Uzbekova S . N-3 polyunsaturated fatty acid DHA during IVM affected oocyte developmental competence in cattle. Theriogenology. 2016; 85(9):1625-1634.e2. DOI: 10.1016/j.theriogenology.2016.01.019. View

Van Blerkom J . Mitochondrial function in the human oocyte and embryo and their role in developmental competence. Mitochondrion. 2010; 11(5):797-813. DOI: 10.1016/j.mito.2010.09.012. View

Baccolo G, Stamerra G, Coppola D, Orlandi I, Vai M . Mitochondrial Metabolism and Aging in Yeast. Int Rev Cell Mol Biol. 2018; 340:1-33. DOI: 10.1016/bs.ircmb.2018.05.001. View

Li Q, Miao D, Zhou P, Wu Y, Gao D, Wei D . Glucose metabolism in mouse cumulus cells prevents oocyte aging by maintaining both energy supply and the intracellular redox potential. Biol Reprod. 2011; 84(6):1111-8. DOI: 10.1095/biolreprod.110.089557. View

Lin P, Su W, Li C, Lin L, Sheu J, Wen Z . Investigating the Role of Ferroptosis-Related Genes in Ovarian Aging and the Potential for Nutritional Intervention. Nutrients. 2023; 15(11). PMC: 10255416. DOI: 10.3390/nu15112461. View

Xu Y, Zhang S, Rong J, Lin Y, Du L, Wang Y . Sirt3 is a novel target to treat sepsis induced myocardial dysfunction by acetylated modulation of critical enzymes within cardiac tricarboxylic acid cycle. Pharmacol Res. 2020; 159:104887. DOI: 10.1016/j.phrs.2020.104887. View

Xie H, Zhu S, Zhang J, Wen J, Yuan H, Pan L . Glucose metabolism during in vitro maturation of mouse oocytes: An study using RNA interference. J Cell Physiol. 2018; 233(9):6952-6964. DOI: 10.1002/jcp.26484. View

10.

Su G, Fiala-Beer E, Weber J, Jahn D, Robertson G, Murray M . Pretranslational upregulation of microsomal CYP4A in rat liver by intake of a high-sucrose, lipid-devoid diet containing orotic acid. Biochem Pharmacol. 2005; 69(4):709-17. DOI: 10.1016/j.bcp.2004.11.005. View

11.

Mailloux R . An Update on Mitochondrial Reactive Oxygen Species Production. Antioxidants (Basel). 2020; 9(6). PMC: 7346187. DOI: 10.3390/antiox9060472. View

12.

Miao Y, Cui Z, Gao Q, Rui R, Xiong B . Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes. Cell Rep. 2020; 32(5):107987. DOI: 10.1016/j.celrep.2020.107987. View

13.

Morimoto Y, Kankanam Gamage U, Yamochi T, Saeki N, Morimoto N, Yamanaka M . Mitochondrial Transfer into Human Oocytes Improved Embryo Quality and Clinical Outcomes in Recurrent Pregnancy Failure Cases. Int J Mol Sci. 2023; 24(3). PMC: 9917531. DOI: 10.3390/ijms24032738. View

14.

Li C, Lin L, Tsui K . Dehydroepiandrosterone Shifts Energy Metabolism to Increase Mitochondrial Biogenesis in Female Fertility with Advancing Age. Nutrients. 2021; 13(7). PMC: 8308577. DOI: 10.3390/nu13072449. View

15.

Li X, Zhan J, Hou Y, Hou Y, Chen S, Luo D . Coenzyme Q10 Regulation of Apoptosis and Oxidative Stress in HO Induced BMSC Death by Modulating the Nrf-2/NQO-1 Signaling Pathway and Its Application in a Model of Spinal Cord Injury. Oxid Med Cell Longev. 2020; 2019:6493081. PMC: 6930770. DOI: 10.1155/2019/6493081. View

16.

Fontana J, Martinkova S, Petr J, Zalmanova T, Trnka J . Metabolic cooperation in the ovarian follicle. Physiol Res. 2019; 69(1):33-48. PMC: 8565957. DOI: 10.33549/physiolres.934233. View

17.

Cagnone G, Tsai T, Makanji Y, Matthews P, Gould J, Bonkowski M . Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency. Sci Rep. 2016; 6:23229. PMC: 4796791. DOI: 10.1038/srep23229. View

18.

Shen L, Liu J, Luo A, Wang S . The stromal microenvironment and ovarian aging: mechanisms and therapeutic opportunities. J Ovarian Res. 2023; 16(1):237. PMC: 10717903. DOI: 10.1186/s13048-023-01300-4. View

19.

Montjean D, Entezami F, Lichtblau I, Belloc S, Gurgan T, Menezo Y . Carnitine content in the follicular fluid and expression of the enzymes involved in beta oxidation in oocytes and cumulus cells. J Assist Reprod Genet. 2012; 29(11):1221-5. PMC: 3510375. DOI: 10.1007/s10815-012-9855-2. View

20.

Steeves T, Gardner D . Metabolism of glucose, pyruvate, and glutamine during the maturation of oocytes derived from pre-pubertal and adult cows. Mol Reprod Dev. 1999; 54(1):92-101. DOI: 10.1002/(SICI)1098-2795(199909)54:1<92::AID-MRD14>3.0.CO;2-A. View