The Role of Mitochondrial DNA Mutations in Mammalian Aging

Overview

Journal PLoS Genet

Specialty Genetics

Date 2007 Feb 27

PMID 17319745

Citations 86

Authors

Gregory C Kujoth

Patrick C Bradshaw

Suraiya Haroon

Tomas A Prolla

Affiliations

Soon will be listed here.

Abstract

Mitochondrial DNA (mtDNA) accumulates both base-substitution mutations and deletions with aging in several tissues in mammals. Here, we examine the evidence supporting a causative role for mtDNA mutations in mammalian aging. We describe and compare human diseases and mouse models associated with mitochondrial genome instability. We also discuss potential mechanisms for the generation of these mutations and the means by which they may mediate their pathological consequences. Strategies for slowing the accumulation and attenuating the effects of mtDNA mutations are discussed.

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