Loss of Bcl-G, a Bcl-2 Family Member, Augments the Development of Inflammation-associated Colorectal Cancer

Overview

Journal Cell Death Differ

Specialty Cell Biology

Date 2019 Jul 13

PMID 31296963

Citations 6

Authors

Paul M Nguyen

Laura F Dagley

Adele Preaudet

Nga Lam

Maybelline Giam

Ka Yee Fung

Kaheina Aizel

Gemma van Duijneveldt

Chin Wee Tan

Yumiko Hirokawa

Hon Yan K Yip

Christopher G Love

Ashleigh R Poh

Akshay D Cruz

Charlotte Burstroem

Rebecca Feltham

Suad M Abdirahman

Kristy Meiselbach

Ronnie Ren Jie Low

Michelle Palmieri

Matthias Ernst

Andrew I Webb

Tony Burgess

Oliver M Sieber

Philippe Bouillet

Tracy L Putoczki

Affiliations

Soon will be listed here.

Abstract

Gastrointestinal epithelial cells provide a selective barrier that segregates the host immune system from luminal microorganisms, thereby contributing directly to the regulation of homeostasis. We have shown that from early embryonic development Bcl-G, a Bcl-2 protein family member with unknown function, was highly expressed in gastrointestinal epithelial cells. While Bcl-G was dispensable for normal growth and development in mice, the loss of Bcl-G resulted in accelerated progression of colitis-associated cancer. A label-free quantitative proteomics approach revealed that Bcl-G may contribute to the stability of a mucin network, which when disrupted, is linked to colon tumorigenesis. Consistent with this, we observed a significant reduction in Bcl-G expression in human colorectal tumors. Our study identifies an unappreciated role for Bcl-G in colon cancer.

Citing Articles

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Dagley L, Yousef J, Preaudet A, Loving A, Webb A, Ernst M Int J Mol Sci. 2024; 25(6).

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Confocal Endomicroscopy Monitoring of Tumor Formation.

Preaudet A, Fung K, Putoczki T Methods Mol Biol. 2023; 2691:257-262.

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BCL-G: 20 years of research on a non-typical protein from the BCL-2 family.

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Inhibition of histone methyltransferase G9a attenuates liver cancer initiation by sensitizing DNA-damaged hepatocytes to p53-induced apoptosis.

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Necroptosis is dispensable for the development of inflammation-associated or sporadic colon cancer in mice.

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