Localization of the Human JUN Protooncogene to Chromosome Region 1p31-32

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1988 Apr 1

PMID 3127828

Citations 21

Authors

F G Haluska

K Huebner

M Isobe

T Nishimura

C M Croce

P K Vogt

Affiliations

Soon will be listed here.

Abstract

The oncogene jun is the putative transforming gene of avian sarcoma virus 17; jun appears to be derived from a gene of the chicken genome and has homologues in several other vertebrate species. Recent genetic and immunological data indicate that jun codes for a protein that is closely related and probably identical to the transcription factor AP-1. We have isolated a genomic DNA clone encompassing the human cellular counterpart of the gene, JUN, and used this DNA to determine the chromosomal location of the gene. A panel of DNA preparations derived from rodent-human somatic cell hybrids with defined chromosome complements was first screened with the JUN probe. This Southern blot analysis indicated that JUN is situated on the short arm of chromosome 1. In situ hybridization then assigned JUN to chromosome region 1p31-32, a chromosomal region involved in both translocations and deletions of chromosomes seen in human malignancies.

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References

Harper M, Saunders G . Localization of single copy DNA sequences of G-banded human chromosomes by in situ hybridization. Chromosoma. 1981; 83(3):431-9. DOI: 10.1007/BF00327364. View

Croce C, Shander M, Martinis J, Cicurel L, DAncona G, Dolby T . Chromosomal location of the genes for human immunoglobulin heavy chains. Proc Natl Acad Sci U S A. 1979; 76(7):3416-9. PMC: 383836. DOI: 10.1073/pnas.76.7.3416. View

Brodeur G, Green A, Hayes F, Williams K, Williams D, Tsiatis A . Cytogenetic features of human neuroblastomas and cell lines. Cancer Res. 1981; 41(11 Pt 1):4678-86. View

Malcolm S, Barton P, Murphy C, Ferguson-Smith M, Bentley D, Rabbitts T . Localization of human immunoglobulin kappa light chain variable region genes to the short arm of chromosome 2 by in situ hybridization. Proc Natl Acad Sci U S A. 1982; 79(16):4957-61. PMC: 346804. DOI: 10.1073/pnas.79.16.4957. View

Dalla-Favera R, Bregni M, Erikson J, Patterson D, Gallo R, Croce C . Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci U S A. 1982; 79(24):7824-7. PMC: 347441. DOI: 10.1073/pnas.79.24.7824. View

Yunis J . The chromosomal basis of human neoplasia. Science. 1983; 221(4607):227-36. DOI: 10.1126/science.6336310. View

Cannizzaro L, Emanuel B . An improved method for G-banding chromosomes after in situ hybridization. Cytogenet Cell Genet. 1984; 38(4):308-9. DOI: 10.1159/000132079. View

Popescu N, Amsbaugh S, DIPAOLO J, Tronick S, Aaronson S, Swan D . Chromosomal localization of three human ras genes by in situ molecular hybridization. Somat Cell Mol Genet. 1985; 11(2):149-55. DOI: 10.1007/BF01534703. View

Huebner K, Palumbo A, Isobe M, Kozak C, Monaco S, Rovera G . The alpha-spectrin gene is on chromosome 1 in mouse and man. Proc Natl Acad Sci U S A. 1985; 82(11):3790-3. PMC: 397873. DOI: 10.1073/pnas.82.11.3790. View

10.

Koufos A, Hansen M, Copeland N, Jenkins N, Lampkin B, Cavenee W . Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism. Nature. 1985; 316(6026):330-4. DOI: 10.1038/316330a0. View

11.

Isobe M, Huebner K, Erikson J, Peterson R, Bollum F, Chang L . Chromosome localization of the gene for human terminal deoxynucleotidyltransferase to region 10q23-q25. Proc Natl Acad Sci U S A. 1985; 82(17):5836-40. PMC: 390648. DOI: 10.1073/pnas.82.17.5836. View

12.

Cavalieri F, Ruscio T, Tinoco R, Benedict S, Davis C, Vogt P . Isolation of three new avian sarcoma viruses: ASV 9, ASV 17, and ASV 25. Virology. 1985; 143(2):680-3. DOI: 10.1016/0042-6822(85)90412-x. View

13.

Hope I, Struhl K . Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast. Cell. 1986; 46(6):885-94. DOI: 10.1016/0092-8674(86)90070-x. View

14.

Friend S, Bernards R, Rogelj S, Weinberg R, Rapaport J, Albert D . A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature. 1986; 323(6089):643-6. DOI: 10.1038/323643a0. View

15.

Lee W, Haslinger A, Karin M, Tjian R . Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40. Nature. 1987; 325(6102):368-72. DOI: 10.1038/325368a0. View

16.

Durst M, Croce C, Gissmann L, Schwarz E, Huebner K . Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas. Proc Natl Acad Sci U S A. 1987; 84(4):1070-4. PMC: 304363. DOI: 10.1073/pnas.84.4.1070. View

17.

Vogt P, Bos T, Doolittle R . Homology between the DNA-binding domain of the GCN4 regulatory protein of yeast and the carboxyl-terminal region of a protein coded for by the oncogene jun. Proc Natl Acad Sci U S A. 1987; 84(10):3316-9. PMC: 304860. DOI: 10.1073/pnas.84.10.3316. View

18.

Maki Y, Bos T, Davis C, Starbuck M, Vogt P . Avian sarcoma virus 17 carries the jun oncogene. Proc Natl Acad Sci U S A. 1987; 84(9):2848-52. PMC: 304757. DOI: 10.1073/pnas.84.9.2848. View

19.

Angel P, Imagawa M, Chiu R, Stein B, Imbra R, Rahmsdorf H . Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell. 1987; 49(6):729-39. DOI: 10.1016/0092-8674(87)90611-8. View

20.

Lee W, Mitchell P, Tjian R . Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements. Cell. 1987; 49(6):741-52. DOI: 10.1016/0092-8674(87)90612-x. View