P K Vogt
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Explore the profile of P K Vogt including associated specialties, affiliations and a list of published articles.
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240
Citations
6970
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Recent Articles
1.
Zhao L, Vogt P
Oncogene
. 2008 Sep;
27(41):5486-96.
PMID: 18794883
Class I phosphoinositide 3-kinase (PI3K) is a dimeric enzyme, consisting of a catalytic and a regulatory subunit. The catalytic subunit occurs in four isoforms designated as p110 alpha, p110 beta,...
2.
Jiang H, Vogt P
Oncogene
. 2008 Jun;
27(43):5729-40.
PMID: 18521078
Rheb (Ras-homolog enriched in brain) is a component of the phosphatidylinositol 3-kinase (PI3K) target of rapamycin (TOR) signaling pathway, functioning as a positive regulator of TOR. Constitutively active mutants of...
3.
Denley A, Kang S, Karst U, Vogt P
Oncogene
. 2007 Nov;
27(18):2561-74.
PMID: 17998941
The catalytic subunits of class I PI3Ks comprise four isoforms: p110alpha, p110beta, p110delta and p110gamma. Cancer-specific gain-of-function mutations in p110alpha have been identified in various malignancies. Cancer-specific mutations in the...
4.
Bader A, Vogt P
Oncogene
. 2007 Aug;
27(8):1179-82.
PMID: 17704806
The Y box-binding protein 1 (YB-1) is a DNA/RNA-binding protein that regulates mRNA transcription and translation. It is a major component of free messenger ribonucleoprotein particles and, at higher concentrations,...
5.
Denning G, Jean-Joseph B, Prince C, Durden D, Vogt P
Oncogene
. 2007 Jan;
26(27):3930-40.
PMID: 17213812
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is an important negative regulator of cell growth and a tumor suppressor. Its growth-attenuating activity is based on the dephosphorylation of...
6.
Aoki M, Vogt P
Curr Top Microbiol Immunol
. 2003 Oct;
279:321-38.
PMID: 14560966
Retroviruses have recruited the catalytic subunit of PI 3-kinase and its downstream target, Akt, as oncogenes. These viruses cause tumors in animals and induce oncogenic transformation in cell culture. The...
7.
8.
Maslyar D, Aoki M, Vogt P
Oncogene
. 2001 Aug;
20(37):5087-92.
PMID: 11526496
Phosphorylation of the Bad protein is a key regulatory event in the prevention of apoptosis by survival factors. Phosphorylated Bad binds to the cytosolic 14-3-3 protein and is sequestered from...
9.
Mende I, Malstrom S, Tsichlis P, Vogt P, Aoki M
Oncogene
. 2001 Jul;
20(32):4419-23.
PMID: 11466625
The kinases Akt2, Akt3 and their myristylated variants, Myr-Akt2 and Myr-Akt3 were expressed by the RCAS vector in chicken embryo fibroblasts (CEF). Myr-Akt2 and Myr-Akt3 were strongly oncogenic, inducing multilayered...
10.
Jiang B, Jiang G, Zheng J, Lu Z, Hunter T, Vogt P
Cell Growth Differ
. 2001 Jul;
12(7):363-9.
PMID: 11457733
The phosphatidylinositol 3-kinase (PI3K) signaling pathway has inherent oncogenic potential. It is up-regulated in diverse human cancers by either a gain of function in PI3K itself or in its downstream...