Endothelial Function and Dysfunction in the Cardiovascular System: the Long Non-coding Road

Overview

Journal Cardiovasc Res

Specialty Cardiology & Vascular Diseases

Date 2019 Jun 20

PMID 31214683

Citations 33

Authors

Joao P Monteiro

Matthew Bennett

Julie Rodor

Axelle Caudrillier

Igor Ulitsky

Andrew H Baker

Affiliations

Soon will be listed here.

Abstract

Present throughout the vasculature, endothelial cells (ECs) are essential for blood vessel function and play a central role in the pathogenesis of diverse cardiovascular diseases. Understanding the intricate molecular determinants governing endothelial function and dysfunction is essential to develop novel clinical breakthroughs and improve knowledge. An increasing body of evidence demonstrates that long non-coding RNAs (lncRNAs) are active regulators of the endothelial transcriptome and function, providing emerging insights into core questions surrounding EC contributions to pathology, and perhaps the emergence of novel therapeutic opportunities. In this review, we discuss this class of non-coding transcripts and their role in endothelial biology during cardiovascular development, homeostasis, and disease, highlighting challenges during discovery and characterization and how these have been overcome to date. We further discuss the translational therapeutic implications and the challenges within the field, highlighting lncRNA that support endothelial phenotypes prevalent in cardiovascular disease.

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