Research Progress on Long Non‑coding RNAs in Non‑infectious Spinal Diseases (Review)

Overview

Journal Mol Med Rep

Specialty Molecular Biology

Date 2024 Jul 12

PMID 38994759

Authors

Zhong Ma

Xin Liu

Xianxu Zhang

Shicheng Li

Jiangdong An

Zhiqiang Luo

Affiliations

Soon will be listed here.

Abstract

Spinal diseases, including intervertebral disc degeneration (IDD), ankylosing spondylitis, spinal cord injury and other non‑infectious spinal diseases, severely affect the quality of life of patients. Current treatments for IDD and other spinal diseases can only relieve symptoms and do not completely cure the disease. Therefore, there is an urgent need to explore the causes of these diseases and develop new treatment approaches. Long non‑coding RNA (lncRNA), a form of non‑coding RNA, is abundant in diverse sources, has numerous functions, and plays an important role in the occurrence and development of spinal diseases such as IDD. However, the mechanism of action of lncRNAs has not been fully elucidated, and significant challenges remain in the use of lncRNAs as new therapeutic targets. The present article reviews the sources, classification and functions of lncRNAs, and introduces the role of lncRNAs in spinal diseases, such as IDD, and their therapeutic potential.

Citing Articles

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Zhang X, Li S, Liu X, Ma Z, Zhang Q, Zhang Y J Orthop Surg Res. 2025; 20(1):122.

PMID: 39891158 PMC: 11783947. DOI: 10.1186/s13018-025-05487-8.

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