The Role of Reactive Oxygen Species in Gastric Cancer

Overview

Journal Cancer Biol Med

Specialty Oncology

Date 2024 Jul 10

PMID 38982978

Authors

Yuqi Wang

Jingli Xu

Zhenjie Fu

Ruolan Zhang

Weiwei Zhu

Qianyu Zhao

Ping Wang

Can Hu

Xiangdong Cheng

Affiliations

Soon will be listed here.

Abstract

Gastric cancer (GC) ranks fifth in cancer incidence and fourth in cancer-related mortality worldwide. Reactive oxygen species (ROS) are highly oxidative oxygen-derived products that have crucial roles in cell signaling regulation and maintaining internal balance. ROS are closely associated with the occurrence, development, and treatment of GC. This review summarizes recent findings on the sources of ROS and the bidirectional regulatory effects on GC and discusses various treatment modalities for GC that are related to ROS induction. In addition, the regulation of ROS by natural small molecule compounds with the highest potential for development and applications in anti-GC research is summarized. The aim of the review is to accelerate the clinical application of modulating ROS levels as a therapeutic strategy for GC.

Citing Articles

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PMID: 39807391 PMC: 11729012. DOI: 10.1016/j.bbrep.2024.101897.

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