Downregulation of an Evolutionary Young MiR-1290 in an IPSC-Derived Neural Stem Cell Model of Autism Spectrum Disorder

Overview

Journal Stem Cells Int

Publisher Wiley

Specialty Cell Biology

Date 2019 Jun 14

PMID 31191687

Citations 19

Authors

Dalia Moore

Brittney M Meays

Lepakshe S V Madduri

Farah Shahjin

Subhash Chand

Meng Niu

Abrar Albahrani

Chittibabu Guda

Gurudutt Pendyala

Howard S Fox

Sowmya V Yelamanchili

Affiliations

Soon will be listed here.

Abstract

The identification of several evolutionary young miRNAs, which arose in primates, raised several possibilities for the role of such miRNAs in human-specific disease processes. We previously have identified an evolutionary young miRNA, miR-1290, to be essential in neural stem cell proliferation and neuronal differentiation. Here, we show that miR-1290 is significantly downregulated during neuronal differentiation in reprogrammed induced pluripotent stem cell- (iPSC-) derived neurons obtained from idiopathic autism spectrum disorder (ASD) patients. Further, we identified that miR-1290 is actively released into extracellular vesicles. Supplementing ASD patient-derived neural stem cells (NSCs) with conditioned media from differentiated control-NSCs spiked with "artificial EVs" containing synthetic miR-1290 oligonucleotides significantly rescued differentiation deficits in ASD cell lines. Based on our earlier published study and the observations from the data presented here, we conclude that miR-1290 regulation could play a critical role during neuronal differentiation in early brain development.

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