Diversity of MicroRNAs in Human and Chimpanzee Brain

Overview

Journal Nat Genet

Specialty Genetics

Date 2006 Oct 31

PMID 17072315

Citations 234

Authors

Eugene Berezikov

Fritz Thuemmler

Linda W van Laake

Ivanela Kondova

Ronald Bontrop

Edwin Cuppen

Ronald H A Plasterk

Affiliations

Soon will be listed here.

Abstract

We used massively parallel sequencing to compare the microRNA (miRNA) content of human and chimpanzee brains, and we identified 447 new miRNA genes. Many of the new miRNAs are not conserved beyond primates, indicating their recent origin, and some miRNAs seem species specific, whereas others are expanded in one species through duplication events. These data suggest that evolution of miRNAs is an ongoing process and that along with ancient, highly conserved miRNAs, there are a number of emerging miRNAs.

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