Epigenetic Control of Stem Cell Fate to Neurons and Glia

Overview

Journal Arch Pharm Res

Specialty Pharmacology

Date 2010 Nov 6

PMID 21052927

Citations 13

Authors

Hyun-Jung Kim

Michael G Rosenfeld

Affiliations

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Abstract

How a cell fate is determined and how tremendously diverse cells are generated during development are interesting and intriguing questions to be solved before using the stem cells for therapeutic purpose. Recently, it has been suggested that epigenetic control by the histone modifying enzymes and non-coding RNAs play important roles in guiding stem cells to differentiate into neurons or glia. In this review, we discuss the recent outcomes and advances in understanding the histone modifying enzymes and non-coding RNAs during neural cell-type specification of stem cells.

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