The Gene Coding for the Human T-lymphocyte CD2 Antigen is Located on Chromosome 1p

Overview

Journal Hum Genet

Specialty Genetics

Date 1987 Jun 1

PMID 3111975

Citations 9

Authors

M H Brown

P A GORMAN

W A Sewell

N K Spurr

D Sheer

M J Crumpton

Affiliations

Soon will be listed here.

Abstract

A cDNA clone encoding the human T lymphocyte sheep erythrocyte receptor [the CD2 (T11) antigen] was used as a probe to define the chromosomal location of the gene. The signal, revealed by hybridisation to Southern blots of genomic DNA from somatic cell hybrids, showed a high degree of concordance for human chromosome 1. In particular, the hybrid F4Sc13C19 which contained the short arm only of human chromosome 1 was positive. The location of the CD2 gene to 1p13 was confirmed by in situ hybridisation.

Citing Articles

Costimulatory Function of Cd58/Cd2 Interaction in Adaptive Humoral Immunity in a Zebrafish Model.

Shao T, Shi W, Zheng J, Xu X, Lin A, Xiang L Front Immunol. 2018; 9:1204.

PMID: 29904386 PMC: 5990624. DOI: 10.3389/fimmu.2018.01204.

Mutational analysis of the CD2/CD58 interaction: the binding site for CD58 lies on one face of the first domain of human CD2.

Somoza C, Driscoll P, Cyster J, Williams A J Exp Med. 1993; 178(2):549-58.

PMID: 7688025 PMC: 2191138. DOI: 10.1084/jem.178.2.549.

Expression of human CD antigens, including CD1 and CD25, by human x mouse interlineage leukaemia hybrids.

Taylor G, Morten H, Carr T, Harrison C, Ridway J, Morris Jones P Immunology. 1987; 62(4):557-65.

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Physical linkage of genes encoding the lymphocyte adhesion molecules CD2 and its ligand LFA-3.

Kingsmore S, Watson M, Moseley W, Seldin M Immunogenetics. 1989; 30(2):123-5.

PMID: 2474492 DOI: 10.1007/BF02421541.

The human LFA-3 gene is located at the same chromosome band as the gene for its receptor CD2.

Sewell W, Palmer R, Spurr N, Sheer D, Brown M, Bell Y Immunogenetics. 1988; 28(4):278-82.

PMID: 2458315 DOI: 10.1007/BF00345506.

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