D Sheer
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Explore the profile of D Sheer including associated specialties, affiliations and a list of published articles.
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Articles
141
Citations
2834
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Recent Articles
1.
Forshew T, Lewis P, Waldman A, Peterson D, Glaser M, Brock C, et al.
Oncogenesis
. 2013 Apr;
2:e41.
PMID: 23545860
Despite an improved understanding of the molecular aberrations that occur in glioblastoma, the use of molecularly targeted therapies have so far been disappointing. We present a patient with three different...
2.
Shipley J, Sheer D
Methods Mol Biol
. 2011 Mar;
7:99-106.
PMID: 21416351
McBride and Ozer (1) were the first to show that purified metaphase chromosomes could act as vectors in transferring genetic information into mammalian cells. This technique, termed chromosome-mediated gene transfer...
3.
Donev R, Newall A, Thome J, Sheer D
Mol Psychiatry
. 2007 Mar;
12(7):681-90.
PMID: 17353911
The beta-amyloid peptide (Abeta) that accumulates in senile plaques in Alzheimer's disease is formed by cleavage of the amyloid precursor protein (APP). The APP gene has several intronic Alu elements...
4.
Shiels C, Islam S, Vatcheva R, Sasieni P, STERNBERG M, Freemont P, et al.
J Cell Sci
. 2001 Nov;
114(Pt 20):3705-16.
PMID: 11707522
Promyelocytic leukemia (PML) bodies are nuclear multi-protein domains. The observations that viruses transcribe their genomes adjacent to PML bodies and that nascent RNA accumulates at their periphery suggest that PML...
5.
Volpi E, Sheer D, Uhlmann F
Curr Biol
. 2001 May;
11(10):R378.
PMID: 11378398
No abstract available.
6.
Abdel-Rahman W, Katsura K, Rens W, GORMAN P, Sheer D, Bicknell D, et al.
Proc Natl Acad Sci U S A
. 2001 Feb;
98(5):2538-43.
PMID: 11226274
The abundant chromosome abnormalities in most carcinomas are probably a reflection of genomic instability present in the tumor, so the pattern and variability of chromosome abnormalities will reflect the mechanism...
7.
Schultz J, Jones T, Bork P, Sheer D, Blencke S, Steyrer S, et al.
Genomics
. 2001 Feb;
71(3):368-70.
PMID: 11170754
Phosphorylated serine- and arginine-rich (SR) proteins play an important role in the formation of spliceosomes, possibly controlling the regulation of alternative splicing. Enzymes that phosphorylate the SR proteins belong to...
8.
Sirivatanauksorn V, Sirivatanauksorn Y, GORMAN P, Davidson J, Sheer D, Moore P, et al.
Int J Cancer
. 2001 Feb;
91(3):350-8.
PMID: 11169959
The molecular events involved in pancreatic cancer are becoming increasingly well characterized, with mutations in the dominant oncogene KRAS and the tumour suppressor genes TP53, CDKN2A and MADH4 being typically...
9.
Jones T, Flomen R, Senger G, Nizetic D, Sheer D
Eur J Cancer
. 2000 Nov;
36(18):2368-74.
PMID: 11094311
Neuroblastoma is a childhood tumour of the sympathetic nervous system that demonstrates striking clinical heterogeneity. In order to determine which genes are abnormally expressed in neuroblastoma, we screened regions of...
10.
Chevret E, Volpi E, Sheer D
Cytogenet Cell Genet
. 2000 Nov;
90(1-2):13-21.
PMID: 11060439
A key feature of interphase chromosomes is their compaction into discrete "territories" in the nucleus. In this review, we focus on the compartmentalization of the genome conferred by this organization...