Genetic Determinants of Weight Loss After Bariatric Surgery

Overview

Journal Obes Surg

Date 2019 Apr 20

PMID 31001758

Citations 15

Authors

Martin Aasbrenn

Theresia Maria Schnurr

Christian Theil Have

Mathilde Svendstrup

Dorte Lindqvist Hansen

Dorte Worm

Marie Balslev-Harder

Mette Hollensted

Niels Grarup

Kristoffer Solvsten Burgdorf

Henrik Vestergaard

Oluf Pedersen

Thorkild I A Sorensen

Mogens Fenger

Sten Madsbad

Torben Hansen

Affiliations

Soon will be listed here.

Abstract

Background: The weight loss after bariatric surgery shows considerable individual variation. Twin studies of response to dietary interventions and studies of bariatric surgery patients suggest that genetic differences may play a role. This study aimed to examine the effect of three genetic risk scores on the inter-individual variation in excess body mass index loss (EBMIL) after Roux-en-Y gastric bypass. Furthermore, we searched among known adiposity-related single nucleotide polymorphisms (SNPs) for genetic determinants of the inter-individual variation in EBMIL.

Methods: Patients with morbid obesity underwent Roux-en-Y gastric bypass and were genotyped (n = 577). Two genetic risk scores for weight loss after bariatric surgery and a genetic risk score for body mass index were calculated. Associations between the genetic risk scores and EBMIL were evaluated. Lasso regression was performed on 126 SNPs known to be associated with adiposity.

Results: The average EBMIL was 76.9% (range 21.7-149.2%). EBMIL was 81.1% (SD 20.6) and 73.9% (SD 21.7) in the high and low tertile groups of a genetic risk score for weight loss. Patients with a low genetic risk score for body mass index (in the lowest 5% percentile) had an EBMIL of 68.8% (SD 20.6, p = 0.018). Thirteen adiposity-related SNPs were identified to associate with EBMIL through lasso regression.

Discussion: A genetic risk score was associated with EBMIL after bariatric surgery, but may not yet be applicable to clinical practice. Patients genetically predisposed to low body mass index had lower weight loss after bariatric surgery.

Citing Articles

Optimizing Nutritional Management Before and After Bariatric Surgery: A Comprehensive Guide for Sustained Weight Loss and Metabolic Health.

Frias-Toral E, Chapela S, Gonzalez V, Martinuzzi A, Locatelli J, Llobera N Nutrients. 2025; 17(4).

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Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery: a multi-ancestry study in 10 960 individuals from 9 biobanks.

German J, Cordioli M, Tozzo V, Urbut S, Arumae K, Smit R medRxiv. 2024; .

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PMID: 39196508 DOI: 10.1007/s11695-024-07474-0.

Longitudinal Profiling of Fasting Plasma Metabolome in Response to Weight-Loss Interventions in Patients with Morbid Obesity.

Chen M, Miao G, Huo Z, Peng H, Wen X, Anton S Metabolites. 2024; 14(2).

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Primary weight loss failure after Roux-en-Y gastric bypass is characterized by impaired gut-hormone mediated regulation of food intake.

Bojsen-Moller K, Svane M, Martinussen C, Dirksen C, Jorgensen N, Jensen J Int J Obes (Lond). 2023; 47(11):1143-1151.

PMID: 37653071 PMC: 10599997. DOI: 10.1038/s41366-023-01372-8.

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