Niels Grarup
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Explore the profile of Niels Grarup including associated specialties, affiliations and a list of published articles.
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Articles
271
Citations
20208
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0
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Recent Articles
1.
Sorensen K, Justesen J, Angquist L, Bork-Jensen J, Hartmann B, Jorgensen N, et al.
Diabetologia
. 2025 Mar;
PMID: 40064676
Aims/hypothesis: An intronic variant (rs10830963) in MTNR1B (encoding the melatonin receptor type 2 [MT2]) has been shown to strongly associate with impaired glucose regulation and elevated type 2 diabetes prevalence....
2.
Staeger F, Andersen M, Li Z, Hjerresen J, He S, Santander C, et al.
Nature
. 2025 Feb;
639(8054):404-410.
PMID: 39939757
Greenlandic Inuit and other indigenous populations are underrepresented in genetic research, leading to inequity in healthcare opportunities. To address this, we performed analyses of sequenced or imputed genomes of 5,996...
3.
Thuesen A, Backe M, Garcia-Erill G, Schubert M, Hanghoj K, Moltke I, et al.
Can J Diabetes
. 2025 Feb;
PMID: 39892506
Objectives: Population studies have identified common genetic variants contributing substantially to the burden of diabetes in Greenland. However, handling of suspected monogenic diabetes in diabetes clinics in Greenland has not...
4.
Suleman S, Huang Y, Jensen R, Poggi A, Christensen S, Fraulund M, et al.
J Clin Endocrinol Metab
. 2024 Dec;
PMID: 39690980
Context: Insulin resistance (IR) is a key factor in the development of cardiometabolic diseases. While genetic risk scores (GRSs) for IR have been developed and validated in adult population, it...
5.
Sass F, Ma T, Ekberg J, Kirigiti M, Urena M, Dollet L, et al.
Nature
. 2024 Nov;
635(8040):987-1000.
PMID: 39537932
The combination of decreasing food intake and increasing energy expenditure represents a powerful strategy for counteracting cardiometabolic diseases such as obesity and type 2 diabetes. Yet current pharmacological approaches require...
6.
Kristensen J, Kjobsted R, Larsen T, Carl C, Hingst J, Onslev J, et al.
Nat Metab
. 2024 Nov;
6(12):2254-2266.
PMID: 39482542
In the Greenlandic Inuit population, 4% are homozygous carriers of a genetic nonsense TBC1D4 p.Arg684Ter variant leading to loss of the muscle-specific isoform of TBC1D4 and an approximately tenfold increased...
7.
Ramne S, Garcia-Urena M, Gillum M, Angquist L, Hansen T, Merino J, et al.
Mol Metab
. 2024 Oct;
90:102049.
PMID: 39426521
Objectives: Experimental and genetic studies suggest that fibroblast growth factor 21 (FGF21) modulates macronutrient and alcohol preferences, but evidence of such regulation in humans remains scarce. To address this gap...
8.
Willems S, Ng N, Fernandez J, Fine R, Wheeler E, Wessel J, et al.
Wellcome Open Res
. 2024 Sep;
8():483.
PMID: 39280063
Background: Genome-wide association studies for glycemic traits have identified hundreds of loci associated with these biomarkers of glucose homeostasis. Despite this success, the challenge remains to link variant associations to...
9.
Huffman J, Nicholas J, Hahn J, Heath A, Raffield L, Yanek L, et al.
Blood
. 2024 Sep;
144(21):2248-2265.
PMID: 39226462
Genetic studies have identified numerous regions associated with plasma fibrinogen levels in Europeans, yet missing heritability and limited inclusion of non-Europeans necessitates further studies with improved power and sensitivity. Compared...
10.
Young W, van der Most P, Bartz T, Bos M, Biino G, Duong T, et al.
J Am Heart Assoc
. 2024 Aug;
13(17):e034760.
PMID: 39206732
Background: Ventricular repolarization time (ECG QT and JT intervals) is associated with malignant arrhythmia. Genome-wide association studies have identified 230 independent loci for QT and JT; however, 50% of their...