Sudachitin Inhibits Matrix Metalloproteinase-1 and -3 Production in Tumor Necrosis Factor-α-Stimulated Human Periodontal Ligament Cells

Overview

Journal Inflammation

Specialties Allergy & Immunology
Pathology

Date 2019 Apr 19

PMID 30997585

Citations 7

Authors

Yoshitaka Hosokawa

Ikuko Hosokawa

Kazumi Ozaki

Takashi Matsuo

Affiliations

Soon will be listed here.

Abstract

Sudachitin, a polymethoxylated flavonoid found in the skin of Citrus sudachi, is a biologically active substance. The aim of this study was to examine whether sudachitin could be used to inhibit the expression of matrix metalloproteinase (MMP)-1 and MMP-3, which are involved in the destruction of periodontal tissues in periodontal lesions, in tumor necrosis factor (TNF)-α-stimulated human periodontal ligament cells (HPDLC). Sudachitin suppressed TNF-α-induced MMP-1 and MMP-3 production in HPDLC. On the other hand, it enhanced tissue inhibitor of metalloproteinase (TIMP)-1 expression. The level of Akt phosphorylation in the TNF-α-stimulated HPDLC was decreased by sudachitin treatment. Moreover, an Akt inhibitor reduced MMP-1 and MMP-3 production and increased TIMP-1 production. These findings indicate that sudachitin reduces MMP-1 and MMP-3 production in TNF-α-stimulated HPDLC by inhibiting the Akt pathway.

Citing Articles

Polymethoxyflavones and Bone Metabolism.

Hirata M, Tominari T, Matsumoto C, Kasuga U, Ikeda K, Miyaura C Nutrients. 2025; 17(5).

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Sudachitin Reduces Inflammatory Mediator Expression in Toll-Like Receptor 2 Ligand-Stimulated Human Dental Pulp Cells.

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Sudachitin and Nobiletin Stimulate Lipolysis via Activation of the cAMP/PKA/HSL Pathway in 3T3-L1 Adipocytes.

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The immunomodulatory role of matrix metalloproteinases in colitis-associated cancer.

He L, Kang Q, Chan K, Zhang Y, Zhong Z, Tan W Front Immunol. 2023; 13:1093990.

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Nobiletin Decreases Inflammatory Mediator Expression in Tumor Necrosis Factor-Stimulated Human Periodontal Ligament Cells.

Hosokawa Y, Hosokawa I, Ozaki K Mediators Inflamm. 2021; 2021:5535844.

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