Gomisin N Decreases Inflammatory Cytokine Production in Human Periodontal Ligament Cells

Overview

Journal Inflammation

Specialties Allergy & Immunology
Pathology

Date 2016 Nov 30

PMID 27896541

Citations 3

Authors

Yoshitaka Hosokawa

Ikuko Hosokawa

Satoru Shindo

Kazumi Ozaki

Takashi Matsuo

Affiliations

Soon will be listed here.

Abstract

Gomisin N, which is a lignan isolated from Schisandra chinensis, has some pharmacological effects. However, the anti-inflammatory effects of gomisin N on periodontal disease are uncertain. The aim of this study was to examine the effect of gomisin N on inflammatory mediator production in tumor necrosis factor (TNF)-α-stimulated human periodontal ligament cells (HPDLC). Gomisin N inhibited interleukin (IL)-6, IL-8, CC chemokine ligand (CCL) 2, and CCL20 production in TNF-α-stimulated HPDLC in a dose-dependent manner. Moreover, we revealed that gomisin N could suppress extracellular signal-regulated kinase (ERK) and c-Jun N terminal kinase (JNK) phosphorylation in TNF-α-stimulated HPDLC though protein kinase B (Akt) phosphorylation was not suppressed by gomisin N treatment. In summary, gomisin N might exert anti-inflammatory effects by attenuating cytokine production in periodontal ligament cells via inhibiting the TNF-α-stimulated ERK and JNK pathways activation.

Citing Articles

Nobiletin Decreases Inflammatory Mediator Expression in Tumor Necrosis Factor-Stimulated Human Periodontal Ligament Cells.

Hosokawa Y, Hosokawa I, Ozaki K Mediators Inflamm. 2021; 2021:5535844.

PMID: 34335088 PMC: 8289582. DOI: 10.1155/2021/5535844.

Nobiletin Inhibits Inflammatory Reaction in Interleukin-1β-Stimulated Human Periodontal Ligament Cells.

Hosokawa Y, Hosokawa I, Ozaki K, Matsuo T Pharmaceutics. 2021; 13(5).

PMID: 34066937 PMC: 8148442. DOI: 10.3390/pharmaceutics13050667.

Sudachitin Inhibits Matrix Metalloproteinase-1 and -3 Production in Tumor Necrosis Factor-α-Stimulated Human Periodontal Ligament Cells.

Hosokawa Y, Hosokawa I, Ozaki K, Matsuo T Inflammation. 2019; 42(4):1456-1462.

PMID: 30997585 DOI: 10.1007/s10753-019-01007-z.

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