Lymphocyte Subpopulations in Adult Coeliac Disease

Overview

Journal Gut

Specialty Gastroenterology

Date 1978 Oct 1

PMID 309420

Citations 10

Authors

A W Bullen

M S Losowsky

Affiliations

Soon will be listed here.

Abstract

Rosetting techniques were used to estimate T and B cell subpopulations in the peripheral blood in patients with treated and untreated adult coeliac disease and in control subjects. In patients with untreated coeliac disease, T cell numbers were significantly lower than in controls or treated patients, although there was no difference in total lymphocyte counts. There was no significant difference in B cell numbers between treated and untreated patients, and the subpopulation which increased to replace the T cells in untreated patients comprised cells not identified by B or T cell markers. Total lymphocyte counts and lymphocyte subpopulations were affected by splenic atrophy. It is suggested that these effects might be caused by the loss of lymphocytes from the gastrointestinal tract in untreated coeliac disease.

Citing Articles

Apoptosis and peripheral blood lymphocyte depletion in coeliac disease.

di Sabatino A, DAlo S, Millimaggi D, Ciccocioppo R, Parroni R, Sciarra G Immunology. 2001; 103(4):435-40.

PMID: 11529933 PMC: 1783265. DOI: 10.1046/j.1365-2567.2001.01245.x.

Phenotyping of peripheral blood lymphocytes in adult coeliac disease.

di Sabatino A, Bertrandi E, Casadei Maldini M, Pennese F, Proietti F, Corazza G Immunology. 1999; 95(4):572-6.

PMID: 9893047 PMC: 1364354. DOI: 10.1046/j.1365-2567.1998.00651.x.

Hyposplenism, adult coeliac disease, and autoimmunity.

Bullen A, Hall R, Gowland G, Rajah S, Losowsky M Gut. 1981; 22(1):28-33.

PMID: 7461474 PMC: 1419299. DOI: 10.1136/gut.22.1.28.

Lymphadenopathy in coeliac disease.

Simmonds J, ROSENTHAL F Gut. 1981; 22(9):756-8.

PMID: 7297925 PMC: 1419877. DOI: 10.1136/gut.22.9.756.

Cellular immunity in children with coeliac disease.

Musumeci S, Patane R, Bottaro G Eur J Pediatr. 1982; 139(4):306-7.

PMID: 7182191 DOI: 10.1007/BF00442189.

References

Meuwissen S, Feltkamp-Vroom T, de la Riviere A, von dem Borne A, Tytgat G . Analysis of the lympho-plasmacytic infiltrate in Crohn's disease with special reference to identification of lymphocyte-subpopulations. Gut. 1976; 17(10):770-80. PMC: 1411187. DOI: 10.1136/gut.17.10.770. View

Thomas H, Freni M, de Villiers D, Jain S, Sherlock S . Peripheral blood lymphocyte populations in chronic liver disease. Clin Exp Immunol. 1976; 26(2):222-7. PMC: 1540859. View

Scott B, Losowsky M . Depressed cell-mediated immunity in coeliac disease. Gut. 1976; 17(11):900-5. PMC: 1411220. DOI: 10.1136/gut.17.11.900. View

HARRIS O, COOKE W, Thompson H, Waterhouse J . Malignancy in adult coeliac disease and idiopathic steatorrhoea. Am J Med. 1967; 42(6):899-912. DOI: 10.1016/0002-9343(67)90071-x. View

Austad W, Cornes J, GOUGH K, McCarthy C, Read A . Steatorrhea and malignant lymphoma. The relationship of malignant tumors of lymphoid tissue and celiac disease. Am J Dig Dis. 1967; 12(5):475-90. DOI: 10.1007/BF02233180. View

BLECHER T, McCarthy C, Read A . Serum immunoglobulins and lymphocyte transformation studies in coeliac disease. Gut. 1969; 10(1):57-62. PMC: 1552703. DOI: 10.1136/gut.10.1.57. View

Griscelli C, Vassalli P . The gut-associated lymphoid system: nature and properties of the large dividing cells. Eur J Immunol. 1974; 4(6):435-43. DOI: 10.1002/eji.1830040610. View

. Immunodeficiency disease and malignancy. Various immunologic deficiencies of man and the role of immune processes in the control of malignant disease. Ann Intern Med. 1972; 77(4):605-28. View

Weiden P, Blaese R, Strober W, Block J, Waldmann T . Impaired lymphocyte transformation in intestinal lymphangiectasia: evidence for at least two functionally distinct lymphocyte populations in man. J Clin Invest. 1972; 51(6):1319-25. PMC: 292269. DOI: 10.1172/JCI106928. View

10.

Bach J . The mode of action of thymic hormones and its relevance to T-cell differentiation. Transplant Proc. 1976; 8(2):243-8. View

11.

Anthony H, Kirk J, Madsen K, MASON M, Templeman G . E and EAC rosetting lymphocytes in patients with carcinoma of bronchus I. Some parameters of the test and of its prognostic significance. Clin Exp Immunol. 1975; 20(1):29-40. PMC: 1538183. View

12.

ODonoghue D, Lancaster-Smith M, Laviniere P, Kumar P . T cell depletion in untreated adult coeliac disease. Gut. 1976; 17(5):328-31. PMC: 1411143. DOI: 10.1136/gut.17.5.328. View

13.

Bohs C, Harris N, Thomson P, Fish J, Traber D . T lymphocyte depletion in peripheral blood of sheep undergoing chronic thoracic duct drainage. J Reticuloendothel Soc. 1976; 19(6):383-8. View

14.

Douglas A, Weetman A, HAGGITH J . The distribution and enteric loss of 51Cr-labelled lymphocytes in normal subjects and in patients with coeliac disease and other disorders of the small intestine. Digestion. 1976; 14(1):29-43. DOI: 10.1159/000197797. View

15.

Ferguson A, Murray D . Quantitation of intraepithelial lymphocytes in human jejunum. Gut. 1971; 12(12):988-94. PMC: 1411995. DOI: 10.1136/gut.12.12.988. View

16.

Fish J, Beathard G, SARLES H, REMMERS Jr A, RITZMANN S . Circulating lymphocyte depletion: effect on lymphoid tissue. Surgery. 1970; 67(4):658-66. View

17.

McCarthy C, Fraser I, EVANS K, Read A . Lymphoreticular dysfunction in idiopathic steatorrhoea. Gut. 1966; 7(2):140-8. PMC: 1552351. DOI: 10.1136/gut.7.2.140. View