Increased Concanavalin A Induced Suppression in Treated and Untreated Coeliac Disease

Overview

Journal Gut

Specialty Gastroenterology

Date 1984 Jun 1

PMID 6234210

Citations 2

Authors

C OFarrelly

U McKeever

C Feighery

D G Weir

Affiliations

Soon will be listed here.

Abstract

The generation of suppression by concanavalin A in peripheral blood mononuclear cells in treated and untreated coeliac subjects using an in vitro assay was found to be significantly increased when compared with controls. The response of peripheral blood mononuclear cells to the plant mitogen concanavalin A (con A) was also significantly depressed in both groups of coeliac patients. It is proposed that the depressed cell mediated immunity found in this and other studies in coeliac patients is because of increased suppression. The possible connection between these findings and the increased incidence of malignancy also found in coeliac disease is discussed.

Citing Articles

The microenvironment of coeliac disease: T cell phenotypes and expression of the T2 'T blast' antigen by small bowel lymphocytes.

Malizia G, Trejdosiewicz L, Wood G, Howdle P, Janossy G, Losowsky M Clin Exp Immunol. 1985; 60(2):437-46.

PMID: 3159529 PMC: 1577031.

Gluten specific suppressor T cell dysfunction in coeliac disease.

Corazza G, Sarchielli P, Londei M, Frisoni M, Gasbarrini G Gut. 1986; 27(4):392-8.

PMID: 2937697 PMC: 1433388. DOI: 10.1136/gut.27.4.392.

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