T Cell Depletion in Untreated Adult Coeliac Disease

Overview

Journal Gut

Specialty Gastroenterology

Date 1976 May 1

PMID 1084314

Citations 11

Authors

D P ODonoghue

M Lancaster-Smith

P Laviniere

P J Kumar

Affiliations

Soon will be listed here.

Abstract

The proportional and absolute numbers of circulating thymus dependent lymphocytes (T cells) were reduced in untreated patients with coeliac disease but were normal after treatment with a gluten free diet. There was an inverse correlation between circulating T cell numbers and jejunal intraepithelial lymphocytes. This evidence suggests a possible role for T cells in the pathogenesis of coeliac disease and is a further example of disturbed cell mediated immunity in this condition.

Citing Articles

Celiac Crisis Associated with Herpes Simplex Virus Esophagitis.

Chen A, Linz C, Tsay J, Jin M, El-Dika S ACG Case Rep J. 2016; 3(4):e159.

PMID: 27921058 PMC: 5126499. DOI: 10.14309/crj.2016.132.

Apoptosis and peripheral blood lymphocyte depletion in coeliac disease.

di Sabatino A, DAlo S, Millimaggi D, Ciccocioppo R, Parroni R, Sciarra G Immunology. 2001; 103(4):435-40.

PMID: 11529933 PMC: 1783265. DOI: 10.1046/j.1365-2567.2001.01245.x.

Phenotyping of peripheral blood lymphocytes in adult coeliac disease.

di Sabatino A, Bertrandi E, Casadei Maldini M, Pennese F, Proietti F, Corazza G Immunology. 1999; 95(4):572-6.

PMID: 9893047 PMC: 1364354. DOI: 10.1046/j.1365-2567.1998.00651.x.

Lymphadenopathy in coeliac disease.

Simmonds J, ROSENTHAL F Gut. 1981; 22(9):756-8.

PMID: 7297925 PMC: 1419877. DOI: 10.1136/gut.22.9.756.

Primary intestinal lymphomas.

Otto H, Bettmann I, Weltzien J, Gebbers J Virchows Arch A Pathol Anat Histol. 1981; 391(1):9-31.

PMID: 7281490 DOI: 10.1007/BF00589792.

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